Results 81 to 90 of about 2,123 (226)

Naphthylisoquinoline alkaloids: novel agents against the causative pathogens of eumycetoma and actinomycetoma-<i>en route</i> to broad-spectrum antimycetomal drugs. [PDF]

Antimicrob Agents Chemother
Mycetoma is a devastating neglected tropical infection of the subcutaneous tissues. It is caused by fungal and bacterial pathogens recognized as eumycetoma and actinomycetoma, respectively.
Khalid SA, Abd Algaffar S, Tajuddeen N, Lombe BK, Bringmann G.   +4 more
europepmc   +2 more sources

Challenges and recent progress in drug discovery for tropical diseases [PDF]

, 2018
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and impose a heavy economic burden on affected countries. These diseases predominantly affect the world’s poorest people.
A Guidi, A Hoerauf, AF Francisco, AK Kakkar, AK Njamnshi, AN Cowell, B Amadi, B Baragana, B Blasco, B Wahid, Beatriz Baragaña, CA Fux, CD Huston, CE Barry III, CE Coltart, D Sissoko, DA Lamprecht, DG Brown, DI Stanisic, DM Plouffe, DS Shepard, DT Hoagland, E Bushell, E Chatelain, E Chatelain, E Check Hayden, E Tacconelli, E Torreele, E Wit de, F Josephson, F Macintyre, FJ Sanchez-Valdez, FX Blanc, G Priotto, G-Finder, H Myllymaki, Hotez, I Angulo-Barturen, I Kramnik, I Molina, Ian H. Gilbert, ID Olaru, IPFMA, J Keiser, J Liu, J Whitehorn, JG Kublin, JN Burrows, JP Sarathy, JR Perfect, JS McCarthy, JS McCarthy, K Awadzi, K Basile, KH Mayer, KK Irwin, KL Kotloff, L Conteh, LJ Zhan, LL Silver, M Lee, M Matsumoto, MA Hulverson, Manu De Rycker, MB Jimenez-Diaz, MC Field, MC Pawlowic, MF Fromm, ML Ang, ML Hovlid, MS Love, MY Lim, N Ford, N Gyawali, N Lander, N Woodford, NA Meanwell, NJ White, NJ White, NJ White, NR Mansour, OP Singh, P Buscher, P Horvath, P Steinmann, PG Wyatt, PJ Hotez, R Rajasingham, R Taylor, RT Jacobs, S Baker, S Brooker, S Khare, S Sayasone, SA Mikolajczak, SD Pion, SH Xiao, SM Hammer, Suzanne L. Duce, T Paquet, TF Koning-Ward de, TK Warren, TN Wells, U Klarmann-Schulz, UH Manjunatha, UH Manjunatha, V Boldescu, V Mesu, VK Wong, W Checkley, W Moser, W Moser, W Zheng, Warren, World Health Organization, X Li, Y Debing, Y Wang   +117 more
core   +2 more sources

Rare Presentation of Kaposi Sarcoma Mimicking Madura Foot: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Kaposi sarcoma (KS) is a low‐grade angioproliferative tumor primarily associated with HIV but also seen in immunocompetent individuals. Its presentation can mimic infectious diseases such as Madura foot (mycetoma), a chronic granulomatous infection endemic to tropical regions.
Jeminah Nyeenya Nakatudde, Rockie Kisekka, Solomon Kibudde   +2 more
wiley   +1 more source

The Burden of Neglected Tropical Diseases in Rwanda: A Scoping Review

Health Science Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background and Aims Rwanda is among the African countries affected by neglected tropical diseases (NTDs). This scoping review aims to synthesize available information to understand the prevalence, incidence, distribution, morbidity, mortality, and risk factors of NTDs in Rwanda.
Masceline Jenipher Mutsaka‐Makuvaza, Michael Olubusayo Binuyo, Callixte Cyuzuzo, Acsa Igizeneza, Jean Paul Sinumvayo, Oluwaremilekun Grace Ajakaye, Egie Elisha Enabulele, Zororo Chinwadzimba, Ezera Agwu, Nicholas Midzi   +9 more
wiley   +1 more source

Plant‐Based Mycetoma Inhibitors Targeting the 50S Ribosomal Protein of Nocardia brasiliensis: In Silico Approach

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
In‐silico drug discovery pipeline for Mycetoma caused by Nocardia brasiliensis. A library of 1034 phytocompounds was screened to identify potent inhibitors, with Parviflorone F showing strong binding and stability against the 50S ribosomal unit. Molecular dynamics confirmed its inhibitory potential, offering a promising therapeutic candidate.
Sandra Jose, Manjunathan Jagadeesan, Meenambiga Setti Sudharsan, Pasiyappazham Ramasamy, Shyamala Gowri, Muthu Thiruvengadam, Sowmya Hari, Baskar Venkidasamy   +7 more
wiley   +1 more source

Actinomycetoma: An Unusual Case and Literature Review

International Journal of TROPICAL DISEASE & Health, 2022
In the current era of modern medicine, neglected tropical disorders though rare, still remain a cause of significant morbidity in the sufferers. Actinomycetoma is one such disease commonly seen in the rural population of the tropical countries.
L. Sanchitha, R. Bhat, Myfanwy D. Souza, Sukumar Dandekeri, J. Jayaraman, M. Fernandes   +5 more
semanticscholar   +1 more source

Eumycetoma of the Foot in a 70‐Year‐Old Male Farmer

Clinical Case Reports, Volume 13, Issue 2, February 2025.
ABSTRACT Clinicians should consider eumycetoma, actinomycotic mycetoma, and skin cancers in patients from tropical or subtropical regions who present with painless swelling and discharging sinuses. The early histopathology, microbiological studies in conjunction with imaging, are of critical importance in narrowing the differential and starting ...
Allahdad Khan, Saad Masood, Aseel Kamal
wiley   +1 more source

Soil Borne Human Diseases [PDF]

, 2011
Soils are home to a remarkable array of biodiversity with some estimates stating that 25% of the Earth’s species find their home in the soil. Of these organisms, the vast majority are not of any threat to human health, but rather function to provide ...
JEFFERY SIMON LEE, VAN DER PUTTEN Wim
core   +1 more source

Extensive Actinomycetoma Clinical Manifestations and Histopathology: A Case Report

Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2022
Background: Actinomycetoma is a chronic infection of cutis, subcutaneous, bone, and viscera tissue. It is characterized by sinuses containing masses of causative organisms often referred to as "grains." Actinomycetoma is caused by aerobic bacteria, and ...
F. Argentina, Rusmawardiana, Nopriyati, Putri Laksmi Karim   +3 more
semanticscholar   +1 more source

Topical and systemic antifungal therapy for chronic rhinosinusitis [PDF]

, 2018
Background: This review adds to a series of reviews looking at primary medical management options for patients with chronic rhinosinusitis.  Chronic rhinosinusitis is common and characterised by inflammation of the lining of the nose and paranasal ...
Balk, Bent, Braun, Chakrabarti, Chan, Chen, Cho, Chong, Chong, Chong, Corradini, Deka, DeMarcantonio, Drunen, Ebbens, Ebbens, Ebbens, Ebbens, Ebbens, Ebbens, Egger, Erskine, Fokkens, Fokkens, Frigas, Gerlinger, Gerlinger, Gliklich, Gupta, Hashemi, Hastan, Head, Head, Head, Helbling, Hofman, Hopkins, Jiang, Jiang, Joshi, Juniper, Kennedy, Kern, Keswani, Khalil, Lackner, Larsen, Liang, Lopatin, Mistry, Nikakhlagh, Panda, Patro, Philpott, Ponikau, Ponikau, Ragab, Ragab, Ravikumar, Ricchetti, Ricchetti, Rojita, Sacks, Sherris, Shin, Sok, Somu, Tan, Thamboo, Tomassen, Verma, Weschta, Weschta, Wild, Yousefi, Zhang, Zhang, Zhang   +77 more
core   +1 more source