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The RNA-binding protein HuR modulates the expression of the disease-linked <i>CCL2</i> rs1024611G-rs13900T haplotype. [PDF]
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Crystal Structures of Actinomycin D and Actinomycin Z3
Angewandte Chemie International Edition, 1998Untwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which ...
Martina, Schäfer +3 more
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Nature, 1970
NUCLEAR magnetic resonance (NMR) spectroscopy has recently been found useful for investigating the conformations of polypeptides like gramicidin S1,2, valinomicin3 and so on. We now report preliminary conclusions on the conformation of the two peptide lactone rings of actinomycin D4 on the basis of NMR results and theoretical conformational analysis ...
CONTI, Filippo, DE SANTIS, Pasquale
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NUCLEAR magnetic resonance (NMR) spectroscopy has recently been found useful for investigating the conformations of polypeptides like gramicidin S1,2, valinomicin3 and so on. We now report preliminary conclusions on the conformation of the two peptide lactone rings of actinomycin D4 on the basis of NMR results and theoretical conformational analysis ...
CONTI, Filippo, DE SANTIS, Pasquale
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Actinomycins as proteinase inhibitors
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1993A novel actinomycin (Act SG3) from a strain of Streptomyces galbus var. C-72, as well as actinomycin D (Act D) were found to act as competitive inhibitors of serine proteinases from microorganisms. The inhibitory properties of Act SG3 and Act D are compared with these of other peptide antibiotics, namely bacitracin A (Bac A) and gramicidin S (Gr S ...
C, Betzel +3 more
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Conformational studies on actinomycin
Biopolymers, 1972AbstractA model of the Actinomycin structure is derived on the basis of theoretical calculations taking into account available IR, NMR and x‐ray experimental data. This model contains two intercycle hydrogen bonds and accounts for all the experimental evidence.
De Santis P., RIZZO, ROBERTO, Ughetto G.
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Actinomycin and Antitumor Antibiotics
American Journal of Clinical Pathology, 1969Actinomycin D forms a stable complex with DNA and thereby inhibits theDNA-dependentsynthesisof RNA. The biochemical effectsof this antibiotic upon cells in culture are interpretable in terms of the complex described above. They include inhibition of the synthesis of ribosomal RNA at low drug concentrations, of all RNA species at moderate concentrations
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Kristallstrukturen von Actinomycin D und Actinomycin Z3
Angewandte Chemie, 1998Unverzwillingte, bis zu atomarer Auflosung streuende Einkristalle konnten erstmals von den Actinomycinen D und Z3 erhalten werden. Tieftemperaturmessungen und die Nutzung neuer Ab-initio-Strukturlosungsmethoden lieferten prazise Kristallstrukturen und ergaben, das z. B.
Martina Schäfer +3 more
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Angewandte Chemie, 1960
AbstractEs wird zusammenfassend über Arbeiten zur Konstitutionsaufklärung und Synthese der Actinomycine berichtet. Anschließend werden die strukturellen Unterschiede, die Biosynthese, die Nomenklatur und die Derivate der Actinomycine erörtert.
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AbstractEs wird zusammenfassend über Arbeiten zur Konstitutionsaufklärung und Synthese der Actinomycine berichtet. Anschließend werden die strukturellen Unterschiede, die Biosynthese, die Nomenklatur und die Derivate der Actinomycine erörtert.
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