Molecular Details of Actinomycin D-Treated MRSA Revealed via High-Dimensional Data [PDF]
Marine Drugs, 2022 Methicillin-resistant Staphylococcus aureus (MRSA) is highly concerning as a principal infection pathogen. The investigation of higher effective natural anti-MRSA agents from marine Streptomyces parvulus has led to the isolation of actinomycin D, that ...
Xuewei Xia +7 more
doaj +2 more sources
Biocontrol of strawberry gray mold caused by Botrytis cinerea with the termite associated Streptomyces sp. sdu1201 and actinomycin D [PDF]
Frontiers in Microbiology, 2022 Strawberry gray mold caused by Botrytis cinerea is one of the most severe diseases in pre- and post-harvest periods. Although fungicides have been an effective way to control this disease, they can cause serious “3R” problems (Resistance, Resurgence and ...
Daojing Yong +13 more
doaj +2 more sources
Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification [PDF]
Pharmaceutics, 2021 Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood–brain barrier. To evaluate its potential applicability for the treatment of patients with central nervous system (CNS) tumors, we ...
Julia Benzel +10 more
doaj +2 more sources
In vitro and in silico evaluations of actinomycin X2and actinomycin D as potent anti-tuberculosis agents [PDF]
PeerJ, 2023 Background Multidrug-resistant tuberculosis (MDR-TB) is one of the world’s most devastating contagious diseases and is caused by the MDR-Mycobacterium tuberculosis (MDR-Mtb) bacteria.
Kamal Ahmad Qureshi +8 more
doaj +3 more sources
Comparing biweekly single-dose actinomycin D with multiday methotrexate therapy for low-risk gestational trophoblastic neoplasia (FIGO Score 0–4): study protocol for a prospective, multicentre, randomized trial [PDF]
BMC Cancer, 2023 Background Single-agent chemotherapy using methotrexate or actinomycin D is the first-line treatment for patients with low-risk gestational trophoblastic neoplasia.
Fang Jiang +10 more
doaj +2 more sources
Efficacy of replacing actinomycin-D with carboplatin in Ewing sarcoma consolidation treatment: Single-center experience [PDF]
Journal of Bone Oncology, 2022 Background: Treatment of Ewing sarcoma (ES) requires multidisciplinary approach and deficiencies in treatment adversely affect the results. This study included patients diagnosed with ES and aimed to determine the factors affecting prognosis and ...
Ayşe Özkan +4 more
doaj +2 more sources
Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23 [PDF]
Scientific Reports, 2021 Streptomyces smyrnaeus UKAQ_23, isolated from the mangrove-sediment, collected from Jubail,Saudi Arabia, exhibited substantial antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), including non-MRSA Gram-positive test ...
Kamal A. Qureshi +15 more
doaj +2 more sources
Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor [PDF]
Cell Reports MedicineSummary: Wilms tumor is the most common pediatric kidney cancer, and diffuse anaplastic Wilms tumor is the most chemoresistant subtype. Here, we explore how Wilms tumor cells evade the chemotherapy actinomycin D, which inhibits ribosomal RNA biogenesis ...
Patricia D.B. Tiburcio +3 more
doaj +2 more sources
Marine Drugs, 2019 Actinomycin V, an analog of actinomycin D produced by the marine-derived actinomycete Streptomyces sp., possessing a 4-ketoproline instead of a 4-proline in actinomycin D.
Fu-Juan Jia, Zhuo Han, Wei-Dong Xie
exaly +3 more sources
Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073 [PDF]
Marine Drugs, 2019 Bioactive secondary metabolites from Streptomycetes are important sources of lead compounds in current drug development. Streptomyces costaricanus SCSIO ZS0073, a mangrove-derived actinomycete, produces actinomycin D, a clinically used therapeutic for ...
Mengchan Liu +6 more
doaj +2 more sources