Identification and characterization of Streptomyces flavogriseus NJ-4 as a novel producer of actinomycin D and holomycin [PDF]
PeerJ, 2017 This paper is the first public report that Streptomyces flavogriseus can produce both actinomycin D and holomycin. The actinomycete strain NJ-4 isolated from the soil of Nanjing Agricultural University was identified as S. flavogriseus.
Zhaohui Wei +5 more
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Identification and application of a strong bidirectional acmN2p promoter from actinomycin D-producing streptomycetes [PDF]
Engineering MicrobiologyNatural product biosynthesis is controlled at multiple levels. Characterization of naturally occurring promoters has facilitated the study of the synthetic biology of natural products. Herein, we report the discovery of two high-yield actinomycin D (ActD)
Sainan Li +6 more
doaj +2 more sources
Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling. [PDF]
PLoS ONE, 2018 Increasing evidence indicates that the Golgi apparatus plays active roles in cancer, but a comprehensive understanding of its functions in the oncogenic transformation has not yet emerged.
Charlotte Luchsinger +4 more
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Marine Drugs, 2019 Actinomycin V, extracted and separated from marine-derived actinomycete Streptomyces sp., as the superior potential replacement of actinomycin D (which showed defect for its hepatotoxicity) has revealed an ideal effect in the suppression of migration and
Fu-Juan Jia, Jia-Hui Ma, Zhuo Han
exaly +3 more sources
Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy. [PDF]
Cancer Discov, 2021 Oncogenic NPM1c mutations prime acute myeloid leukemia cells for mitochondrial targeting by actinomycin D, which restores PML nuclear bodies—driven senescence and is synergistic with venetoclax to induce tumor clearance.
Wu HC +35 more
europepmc +2 more sources
Multi-Omics Analysis Reveals Anti-Staphylococcus aureus Activity of Actinomycin D Originating from Streptomyces parvulus. [PDF]
Int J Mol Sci, 2021 Staphylococcus aureus (S. aureus) is a common pathogen that causes various serious diseases, including chronic infections. Discovering new antibacterial agents is an important aspect of the pharmaceutical field because of the lack of effective ...
Lin Y +7 more
europepmc +2 more sources
Actinomycin D-induced bilateral optic nerve atrophy: a case report [PDF]
International Journal of OphthalmologyKe Zhu +5 more
doaj +2 more sources
Effect of SDS Micelles on Actinomycin D – DNA Complexes
Acta Chimica Slovenica, 2022 DNA thermal denaturation was evaluated as a measure of the effect of antitumor drug actinomycin D on the stability of the double helix and also the effect of SDS micelles on actinomycin D – DNA complexes.
Ana Maria Toader +2 more
doaj +1 more source
Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover. [PDF]
Methods, 2019 Decay of transcribed mRNA is a key determinant of steady state mRNA levels in cells. Global analysis of mRNA decay in cultured cells has revealed amazing heterogeneity in rates of decay under normal growth conditions, with calculated half-lives ranging ...
Lai WS +3 more
europepmc +2 more sources
mRNA Stability Assay Using transcription inhibition by Actinomycin D in Mouse Pluripotent Stem Cells. [PDF]
Bio Protoc, 2018 Gene expression is regulated through multiple steps at both transcriptional and post-transcriptional levels. The net abundance of mature mRNA species in cells is determined by the balance between transcription and degradation.
Ratnadiwakara M, Änkö ML.
europepmc +2 more sources