Results 1 to 10 of about 45,752 (117)
Marine Drugs, 2019 Actinomycin V, an analog of actinomycin D produced by the marine-derived actinomycete Streptomyces sp., possessing a 4-ketoproline instead of a 4-proline in actinomycin D.
Fu-Juan Jia, Zhuo Han, Wei-Dong Xie
exaly +3 more sources
Marine Drugs, 2019 Actinomycin V, extracted and separated from marine-derived actinomycete Streptomyces sp., as the superior potential replacement of actinomycin D (which showed defect for its hepatotoxicity) has revealed an ideal effect in the suppression of migration and
Fu-Juan Jia, Jia-Hui Ma, Zhuo Han
exaly +3 more sources
Actinomycin Analogs from Soil-Derived Streptomyces sp. PSU-S4-23 with Activity Against MRSA [PDF]
LifeGenome-based discovery provides a powerful approach for identifying bioactive natural products. In this study, Streptomyces sp. PSU-S4-23 was isolated from soil collected in southern Thailand.
Chollachai Klaysubun +5 more
doaj +2 more sources
Journal of Marine Science and Engineering, 2023 Marine symbiotic actinomycetes play a key role in drug development and their ecological niches can influence a variety of natural product biosynthesis, providing potential defensive benefits. In this study, we report the whole-genome sequence analysis of
Ganesan Govindarajan +7 more
doaj +1 more source
"Cara inchada" of cattle, an infectious, apparently soil antibiotics-dependant periodontitis in Brazil [PDF]
Pesquisa Veterinária Brasileira, 2000 The objective of this review on the investigation of "cara inchada" in cattle (CI), pursued over the last 30 years, was to elucidate the pathogenicity of the disease and come to proper conclusions on its etiology.
Jürgen Döbereiner +3 more
doaj +1 more source
Adherence and experimental infection of bacteria associated with periodontal infections of young cattle in Brazil ("Cara inchada") [PDF]
Pesquisa Veterinária Brasileira, 1997 In vitro- and in vivo-assays were conducted, to study the possible role of streptomycin- and actinomycin-producing soil actinomycetes for the pathogenesis of "Cara inchada" in cattle (CI). Adherence of Bacteroides spp.
Barbara Grassmann +4 more
doaj +1 more source
Pharmaceutics, 2021 Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood–brain barrier. To evaluate its potential applicability for the treatment of patients with central nervous system (CNS) tumors, we ...
Julia Benzel +10 more
doaj +1 more source
Discovery of actinomycin L, a new member of the actinomycin family of antibiotics
Scientific Reports, 2022 Streptomycetes are major producers of bioactive natural products, including the majority of the naturally produced antibiotics. While much of the low-hanging fruit has been discovered, it is predicted that less than 5% of the chemical space of natural ...
Nataliia V. Machushynets +7 more
doaj +1 more source
In vitro and in silico evaluations of actinomycin X2and actinomycin D as potent anti-tuberculosis agents [PDF]
PeerJ, 2023 Background Multidrug-resistant tuberculosis (MDR-TB) is one of the world’s most devastating contagious diseases and is caused by the MDR-Mycobacterium tuberculosis (MDR-Mtb) bacteria.
Kamal Ahmad Qureshi +8 more
doaj +2 more sources
Frontiers in Microbiology, 2020 Streptomycetes, typical soil dwellers, can be detected as common colonizers of human bodies, especially the skin, the respiratory tract, the guts and the genital tract using molecular techniques.
Andrej Herbrík +12 more
doaj +1 more source