Results 31 to 40 of about 45,871 (227)

Modulating the Release Kinetics of Natural Product Actinomycin from Bacterial Nanocellulose Films and Their Antimicrobial Activity

Bioengineering
The present study aimed to create a more sustainable and controlled delivery system based on natural biopolymer bacterial nanocellulose (BNC) and bacterial natural product actinomycin (Act), with the applicative potential in the biomedical field.
Katarzyna Zimowska, Vuk Filipovic, Jasmina Nikodinovic-Runic, Jelena Simic, Tatjana Ilic-Tomic, Malgorzata Zimowska, Jacek Gurgul, Marijana Ponjavic   +7 more
doaj   +1 more source

Embryonal Paratesticular Rhabdomyosarcoma Masquerading as an Inguinal Hernia: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Embryonal paratesticular rhabdomyosarcoma can mimic benign inguinoscrotal conditions such as inguinal hernia. In children with persistent, painless scrotal masses, early cross‐sectional imaging and prompt radical inguinal orchiectomy with histopathological confirmation are essential.
Al Kiswani S, Otoum Q, Abbas M, Sawafta M, Salih A, Jaber O, Gharaibeh A, Nofal A.   +7 more
europepmc   +2 more sources

Actinomycin Resistance and Actinomycin Excretion in a Mutant of Escherichia coli [PDF]

Journal of Bacteriology, 1970
A mutant of Escherichia coli resembles its parent in taking up actinomycin after treatment with ethylenediaminetetraacetic acid but differs in that it survives this uptake and excretes actinomycin at an increased rate.
M J, Voll, L, Leive
openaire   +2 more sources

In Vitro and In Silico Approaches for the Antileishmanial Activity Evaluations of Actinomycins Isolated from Novel Streptomyces smyrnaeus Strain UKAQ_23

Antibiotics, 2021
Leishmaniasis, a Neglected Tropical Parasitic Disease (NTPD), is induced by several Leishmania species and is disseminated through sandfly (Lutzomyia longipalpis) bites. The parasite has developed resistance to currently prescribed antileishmanial drugs,
Kamal A. Qureshi, Ibrahim Al Nasr, Waleed S. Koko, Tariq A. Khan, M. Qaiser Fatmi, Mahrukh Imtiaz, Riaz A. Khan, Hamdoon A. Mohammed, Mariusz Jaremko, Abdul-Hamid Emwas, Faizul Azam, Avinash D. Bholay, Gamal O. Elhassan, Dinesh K. Prajapati   +13 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Anti-Klebsiella pneumoniae activity of secondary metabolism of Achromobacter from the intestine of Periplaneta americana

BMC Microbiology, 2023
Background Klebsiella pneumoniae is one of the main pathogens of clinical isolation and nosocomial infections, as K. pneumoniae show broad-spectrum resistance to β-lactam and carbapenem antibiotics.
Yan Ma, Ping Guo, Xueqin Chen, Minhua Xu, Wenbin Liu, Xiaobao Jin   +5 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Hypertrophic Cardiomyopathy Mutation R723G in MYH7 Enhances Its mRNA-Stability. [PDF]

Acta Physiol (Oxf)
Acta Physiologica, Volume 242, Issue 6, June 2026.
Kowalski K, Schwarze L, Kraft T, Montag J.   +3 more
europepmc   +2 more sources

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source