Results 21 to 30 of about 45,871 (227)
Heliyon, 2023 Invasive fungal infections are on the rise, leading to a continuous demand for antifungal antibiotics. Rare actinomycetes have been shown to contain a variety of interesting compounds worth exploring.
Wenbin Liu +7 more
doaj +1 more source
Mex-3 RNA-binding family member A limits macrophage ferroptosis-associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis. [PDF]
Clin Transl MedDiabetes reduces macrophage MEX3A and aggravates atherosclerotic plaque instability. MEX3A stabilises Slc7a11 and Gpx4 mRNAs to sustain SLC7A11/GPX4 antioxidant defence. MEX3A deficiency promotes macrophage ferroptosis, lipid peroxidation and mitochondrial injury. Ferrostatin‐1 partially attenuates ferroptotic injury and diabetic plaque destabilisation.
Ma Y +7 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
Differential disruption of EWS-FLI1 binding by DNA-binding agents. [PDF]
PLoS ONE, 2013 Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma.
Changmin Chen +3 more
doaj +1 more source
Comparison between single-agent chemotherapy in low-risk gestational trophoblastic neoplasia
Caspian Journal of Internal Medicine, 2023 Background: Low-risk gestational trophoblastic neoplasia could be cured in the case of appropriate management with single-agent chemotherapy. This study was carried out to compare the efficacy of single-dose methotrexate versus Actinomycin-D in low-risk ...
Leila Mousavi Seresht +2 more
doaj
High density lipoproteins of blood plasma as a transport form of actinomycin D
Сибирский онкологический журнал, 2019 Introduction. The development of new and highly effective antitumor therapy is one of the priorities of pharmacology. The paper presents one of the solutions to the problem related to the development of transport forms of antitumor drugs.The aim of the ...
L. M. Polyakov +4 more
doaj +1 more source
Bioactive secondary metabolites from two sponge-derived actinomycetes
Shenzhen Daxue xuebao. Ligong ban, 2022 Actinomycetes residing in marine habitat are an excellent treasure house of structurally novel and bioactive natural products with potent medicinal values.
GUO Zhikai +5 more
doaj +1 more source
Marine Drugs, 2019 Bioactive secondary metabolites from Streptomycetes are important sources of lead compounds in current drug development. Streptomyces costaricanus SCSIO ZS0073, a mangrove-derived actinomycete, produces actinomycin D, a clinically used therapeutic for ...
Mengchan Liu +6 more
doaj +1 more source
Discovery of a new highly pathogenic toxin involved in insect sepsis
Microbiology Spectrum, 2023 Insect sepsis is a severe consequence that arises from the invasion of the hemocoel by symbionts of entomopathogenic nematodes and bacteria. In the present study, we unveiled the heightened virulence of the entomopathogenic nematode Steinernema feltiae ...
Yuan Zhang +8 more
doaj +1 more source
Journal of Bone Oncology, 2022 Background: Treatment of Ewing sarcoma (ES) requires multidisciplinary approach and deficiencies in treatment adversely affect the results. This study included patients diagnosed with ES and aimed to determine the factors affecting prognosis and ...
Ayşe Özkan +4 more
doaj +1 more source