Results 21 to 30 of about 14,232,320 (254)
Anti-Oxidative and Anti-Apoptotic Effects of Apigenin on Number of Viable and Apoptotic Blastomeres, Zona Pellucida Thickness and Hatching Rate of Mouse Embryos [PDF]
International Journal of Fertility and Sterility, 2018 Background Apigenin is a plant-derived compound belonging to the flavonoids category and bears protective effects on different cells. The aim of this study was to evaluate the effect of apigenin on the number of viable and apoptotic blastomeres, the ...
Manouchehr Safari +4 more
doaj +1 more source
Gynecologic Oncology, 2020 Objectives. Methotrexate and actinomycin-D are both effective first-line drugs for low-risk (WHO score 0–6) Gestational Trophoblastic Neoplasia (GTN) with considerable debate about which is more effective, less toxic, and better tolerated.
J. Schink +12 more
semanticscholar +1 more source
Marine Drugs, 2020 The high toxicity of actinomycin D (Act D) severely limits its use as a first-line chemotherapeutic agent in the clinic. Actinomycin V (Act V), an analog of Act D, exhibited strong anticancer activity in our previous studies.
Fu-juan Jia +7 more
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Discovery of a new highly pathogenic toxin involved in insect sepsis
Microbiology Spectrum, 2023 Insect sepsis is a severe consequence that arises from the invasion of the hemocoel by symbionts of entomopathogenic nematodes and bacteria. In the present study, we unveiled the heightened virulence of the entomopathogenic nematode Steinernema feltiae ...
Yuan Zhang +8 more
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High density lipoproteins of blood plasma as a transport form of actinomycin D
Сибирский онкологический журнал, 2019 Introduction. The development of new and highly effective antitumor therapy is one of the priorities of pharmacology. The paper presents one of the solutions to the problem related to the development of transport forms of antitumor drugs.The aim of the ...
L. M. Polyakov +4 more
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ON THE DIFFERENTIAL CYTOTOXICITY OF ACTINOMYCIN D [PDF]
The Journal of Cell Biology, 1971 Actinomycin D (AMD) at concentrations that inhibit cellular RNA synthesis by 85% or more causes an acute phase of lethal cell degeneration in HeLa cultures beginning as early as 3 hr after drug exposure, resulting in the nearly complete loss of viable cells by 12 hr. The loss of cells during this acute phase of lethality is closely dose dependent. Vero,
S G, Sawicki, G C, Godman
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Differential disruption of EWS-FLI1 binding by DNA-binding agents. [PDF]
PLoS ONE, 2013 Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma.
Changmin Chen +3 more
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Actinomycin D-Induced Hepatotoxicity [PDF]
Pediatric Hematology and Oncology, 1989 Two recent publications have highlighted toxic effects involving the liver in children treated for Wilms' tumor, and the possible role of actinomycin D (AMD). In a letter to the editor of Cancer Treatment Reports, Dr. G. D'Angio, on behalf of the National Wilms' Tumor Study Committee, warned of profound hepatotoxicity experienced in 5 of 40 children ...
L, White, V, Tobias, D W, Hughes
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Antibiotics, 2021 Leishmaniasis, a Neglected Tropical Parasitic Disease (NTPD), is induced by several Leishmania species and is disseminated through sandfly (Lutzomyia longipalpis) bites. The parasite has developed resistance to currently prescribed antileishmanial drugs,
Kamal A. Qureshi +13 more
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Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source