Results 91 to 100 of about 2,127,671 (356)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Penerapan Program Crocodile Physics Sebagai Media Pembelajaran dalam Upaya Meningkatkan Pemahaman Konsep Fisika Siswa

open access: yesIndonesian Journal of Science and Mathematics Education, 2019
:Research In this journal aims to find out the increasing students in understanding the conception of physics through the help of media Crocodile Physics programs. The form of research used in this study is Action Research.
Abdi Novianto, Nirva Diana
doaj   +1 more source

The Principle of Least Action as Interpreted by Nature and by the Observer [PDF]

open access: yesarXiv, 2012
In this paper, we show that the difficulties of interpretation of the principle of least action concerning "final causes" or "efficient causes" are due to the existence of two different actions, the "Euler-Lagrange action" (or classical action) and the "Hamilton-Jacobi action".
arxiv  

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) UNTUK MENINGKATKAN HASIL BELAJAR FISIKA PADA POKOK BAHASAN GEJALA DAN CIRI CIRI GELOMBANG SISWA KELAS XII SMAN 9 PEKANBARU

open access: yesJurnal PAJAR (Pendidikan dan Pengajaran), 2017
This research is motivated by the lack of physics student learning outcomes on feature highlights feature of wave class XII SMAN 9 Pekanbaru. This study aims to improve the learning outcomes of physics students on feature highlights wave characteristics ...
Gustariani Gustariani
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Constraining the UV with the electroweak effective action

open access: yesJournal of High Energy Physics
By considering an arbitrary bare action describing BSM physics, we use the Barvinsky-Vilkovisky resummation to obtain the most general non-local electroweak effective action at second order in the field strength.
Iberê Kuntz, Amanda Malagi
doaj   +1 more source

Do students have sufficient knowledge of physics to take marine biology courses? [PDF]

open access: yesBIO Web of Conferences
Physics and biology are two branches of science that have many connections. In marine biology courses, students must have a good basic concept of physics.
Sarkity Dios   +3 more
doaj   +1 more source

Decoupling in an expanding universe: boundary RG-flow affects initial conditions for inflation

open access: yes, 2004
We study decoupling in FRW spacetimes, emphasizing a Lagrangian description throughout. To account for the vacuum choice ambiguity in cosmological settings, we introduce an arbitrary boundary action representing the initial conditions.
A. Strominger   +41 more
core   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

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