Results 91 to 100 of about 10,981,913 (333)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Strategic implementation of deep learning curriculum in early childhood using the TQM framework
Research and Development in EducationThe lack of structured strategic guidance for implementing a Total Quality Management (TQM)-based deep learning curriculum is a major obstacle in efforts to sustainably improve the quality of early childhood education.
Alifia Arif Maulidya, Achmad Supriyanto
doaj +1 more source
Liberia’s Gender-Based Violence National Action Plan [PDF]
Forced Migration Review, 2007 Liberia is on the path to national recovery after some 14 years of a brutal civil war that left around half of all Liberian women as survivors of gender-based violence (GBV). However, rates of GBV, in particular domestic violence, remain high.
Ellen Johnson Sirleaf
doaj
Integrated approach to strategic planning in public institutions
Journal of Business Economics and Management, 2007 Planning of actions for implementation of institution's strategic decisions is one of the most complicated, on the other hand, the weakest in methodic provision complex objectives of strategic planning.
Juozas Bivainis, Živilė Tunčikienė
doaj +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The River Lyn SAP Final Plan [PDF]
, 2003 This is the River Lyn Salmon Action Plan Final document produced by the Environment Agency in 2003. This final Salmon Action Plan (SAP) for the River Lyn catchment has been produced after consideration of feedback from external consultation.
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Building Place-Based Initiatives for Boys and Men of Color and Vulnerable Populations: A Community Planning Guide [PDF]
, 2015 This guide provides information about how communities can implement the next phase of achieving priority outcomes for boys and men of color. It focuses on two critical areas of work: 1) how to conduct a policy review and formulate recommendations for ...
Lewis Brown, Jr. +2 more
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