Results 101 to 110 of about 3,519,544 (291)

LEARNER AUTONOMY AND INFORMATION SKILLS DEVELOPMENT IN THE FACULTIES OF ARTS AND HUMANITIES

open access: yesВысшее образование в России, 2016
The article describes a course "Learner Autonomy and Information Skills Development Through the Internet In the Faculties of Arts and Humanities" which was developed by request of the Ministry for Education and Science within the project "Remodeling ...
Alevtina B. Klimova   +1 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Funding Sources for Key Water Quality Strategies, Craig, M [PDF]

open access: yes, 2004
The New Hampshire Estuaries Project (NHEP) Management Plan, published in 2000, sets forth three goals related to estuarine water quality in the State’s coastal watershed, and twenty Water Quality Action Plans to implement these goals.
Craig, Matt
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Employment Action Plan : 2002 [PDF]

open access: yes, 2002
"The UK Employment Action Plan 2002 was produced after extensive consultation and agreement across Government Departments and agencies responsible for the employment, economic and social fields.

core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Tackling methamphetamine: indicators and progress report October 2012 [PDF]

open access: yes
This report provides a progress update on the records changes against the Action Plan\u27s baseline data, and details progress on the Action Plan\u27s activities.When the Action Plan was launched, Chief Executives from DPMC, Health, Customs, Justice ...

core  

Home - About - Disclaimer - Privacy