Results 121 to 130 of about 3,519,544 (291)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Revista Geográfica Acadêmica, 2015 Geodiversity Audit is an inventory and assessment process, wich represents the basis for elaborating the Geoconservation Action Plan. The geodiversity includes the abiotic factors (rocks, minerals, soils, landforms) that sustain the life on the Earth,
Ioan Bâca
doaj
Teachers in action: delivering individualized education plan [PDF]
The role of teachers involved is very important for an individualised education plan (IEP) to serve its purpose to children with special needs. This is because they are engaged directly in the programme's implementation and in determining the children's ...
Jiar, Yeo Kee +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Accelerating the SDG3 Global Action Plan
BMJ Global Health, 2019 Robert Marten, Maike Voss, Daniel Gulati
doaj +1 more source
PREPARATION OF ACTION PLAN FOR PROTECTION OF LAND IN ALBANIA [PDF]
The degradation of Albania's land resources is a serious impediment to the welfare of the people of Albania as well as that of future generations. Resolving land degradation requires the concerted action of governmental and nongovernmental agencies.
Bockheim, James G.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The HIV Epidemic in Tanzania Mainland:Where have we come from, Where is it Going, and how are we responding? [PDF]
, 2008 AIDS Strategy & Action Plan, (ASAP)
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source