Results 191 to 200 of about 3,519,544 (291)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Compliance with global action plan on antibiotic prescription and utilization: a multi-facility cross-sectional study in southern Nigeria. [PDF]

BMC Infect Dis
Akpan MR, Eshiet UI, Jackson IL, Etim EO.   +3 more
europepmc   +1 more source

ICT Action Plan [PDF]

, 2012

core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Development and pilot of the BC Wildfire Smoke and Extreme Heat Action Plan: empowering patients with climate health readiness. [PDF]

BMJ Open Qual
He R, Shellington E, Barn P, Rideout K, Bueso A, Joshi I, Maddocks S, Camp PG, Crocker M, Coker E, Afshar T, Turvey J, Brigham E.   +12 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Participatory development of Indonesia's national action plan for zero leprosy: strategies and interventions. [PDF]

Front Public Health
Sebong PH, Ferdiana A, Tegu FAR, Harbianto D, Soviandhi R, Sinaga A, Budiawan T, Risnanto AJAY, Sidjabat RT, Yudopuspito T, Mawardi R, Setyawati E, Utarini A.   +12 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Respective characteristics and contributions of two cataract surgery delivery models to the eye health national action plan in Rwanda. [PDF]

BMC Health Serv Res
Ndayambaje JB, Mazimpaka C, Ndahimana JD, Mutsindashyaka T, Habimana I, Dieu Harerimana J, Kananura T, Mungarulire J, Muzungu HS, Humuza J, Uhawenimana TC, Kabanda R, Dieu Ndagijimana J, Mwangi H, Mumararungu A, Donatien NN, Ndolo C, Kirchhoffer D, Semakula M.   +18 more
europepmc   +1 more source