Results 51 to 60 of about 20,440,250 (309)

Mechanical surface waves accompany action potential propagation [PDF]

open access: yesNature Communications, 2014
Many diverse studies have shown that a mechanical displacement of the axonal membrane accompanies the electrical pulse defining the action potential (AP).
Ahmed El Hady, B. Machta
semanticscholar   +1 more source

Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp

open access: yesFrontiers in Pharmacology, 2021
Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes.
Arie O. Verkerk   +8 more
doaj   +1 more source

Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing

open access: yesNature Communications, 2015
Action potential timing is fundamental to information processing; however, its determinants are not fully understood. Here we report unexpected structural specializations in the Ranvier nodes and internodes of auditory brainstem axons involved in sound ...
Marc C. Ford   +8 more
semanticscholar   +1 more source

Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

open access: yesFrontiers in Pharmacology, 2022
Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, and beverages like fruit juices, tea, coffee and ...
M. Rudrapal   +9 more
semanticscholar   +1 more source

Extending Feynman's Formalisms for Modelling Human Joint Action Coordination

open access: yes, 2009
The recently developed Life-Space-Foam approach to goal-directed human action deals with individual actor dynamics. This paper applies the model to characterize the dynamics of co-action by two or more actors. This dynamics is modelled by: (i) a two-term
Bernstein N. A.   +9 more
core   +1 more source

The DBI Action, Higher-derivative Supergravity, and Flattening Inflaton Potentials [PDF]

open access: yes, 2016
In string theory compactifications it is common to find an effective Lagrangian for the scalar fields with a non-canonical kinetic term. We study the effective action of the scalar position moduli of Type II D$p$-branes.
Bielleman, Sjoerd   +4 more
core   +4 more sources

Breathing is coupled with voluntary action and the cortical readiness potential

open access: yesNature Communications, 2020
Voluntary action is a fundamental element of self-consciousness. The readiness potential (RP), a slow drift of neural activity preceding self-initiated movement, has been suggested to reflect neural processes underlying the preparation of voluntary ...
Hyeong-Dong Park   +5 more
semanticscholar   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale   +6 more
wiley   +1 more source

Dendritic Na+ spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons

open access: yeseLife, 2014
Synaptic inputs from different brain areas are often targeted to distinct regions of neuronal dendritic arbors. Inputs to proximal dendrites usually produce large somatic EPSPs that efficiently trigger action potential (AP) output, whereas inputs to ...
Qian Sun   +3 more
doaj   +1 more source

Computational design of custom therapeutic cells to correct failing human cardiomyocytes

open access: yesFrontiers in Systems Biology, 2023
Background: Myocardial delivery of non-excitable cells—namely human mesenchymal stem cells (hMSCs) and c-kit+ cardiac interstitial cells (hCICs)—remains a promising approach for treating the failing heart. Recent empirical studies attempt to improve such
Andrew Tieu   +6 more
doaj   +1 more source

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