Evolution of action potential with time.
A. Simulated AP of hiPSC-CM model for various percentages of IKr block (0%, 50% and 100%). Action potential duration prolonged with increasing IKr conductance block. B. Simulated AP of rabbit Purkinje cell (RPC) model for various percentages of IKr block
Jacqueline Treat (17743170) +9 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Different Effects of Phenothiazines on Cardiac Action Potential Duration [PDF]
Basic & Clinical Pharmacology & Toxicology, 2005 Won-Ho, Shin, Eun-Joo, Kim
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Predictive Chaos Control for the 1D-map of Action Potential Duration
, 2016 International audienceIn the present work, a nonlinear control method namely predictive controlis investigated. The proposed method allows stabilizing unstable period-1 rhythm.Using mathematical analysis and computer simulations, we show that this ...
Kesmia, Mounira +2 more
core +1 more source
ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of IKr. [PDF]
Pharmaceuticals (Basel), 2023 Kovács ZM +9 more
europepmc +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome. [PDF]
Heart Rhythm O2, 2023 Kim M +8 more
europepmc +1 more source
The transformative possibility of literary métissage: An action research report
, 2019 This report describes and exemplifies ongoing action research advancing an inquiry method with the potential to reveal evidence of individual and collective relational learning resulting from teacher professional development.
MacLeod, Laurie +2 more
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