Results 171 to 180 of about 12,692,953 (333)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Gambierol blocks a K+ current fraction and affects action potential duration and the firing rate in rat fetal chromaffin cells

, 2022
Jordi Molgó, Roland Bournaud, Sébastien Schlumberger, Makoto Sasaki, Haruhiko Fuwa, Évelyne Benoit   +5 more
openalex   +4 more sources

The p.P888L SAP97 polymorphism increases the transient outward current (I_to,f) and abbreviates the action potential duration and the QT interval. [PDF]

Sci Rep, 2020
Tinaquero D, Crespo-García T, Utrilla RG, Nieto-Marín P, González-Guerra A, Rubio-Alarcón M, Cámara-Checa A, Dago M, Matamoros M, Pérez-Hernández M, Tamargo M, Cebrián J, Jalife J, Tamargo J, Bernal JA, Caballero R, Delpón E, ITACA Investigators.   +17 more
europepmc   +1 more source

Facilitated action research: Enhancing the teaching of classroom drama

, 2013
This paper argues for facilitated action research as an effective way of supporting teacher professional learning in drama. It also recognises that the need for support identified in a past study remains current resulting in the facilitated action ...
Perry, Rachel
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Losartan inhibits hyposmotic-induced increase of IKs current and shortening of action potential duration in guinea pig atrial myocytes. [PDF]

Anatol J Cardiol, 2020
Gao J, Tian Y, Xie X, Zhao J, Liu CH, Sheng Y, Cao F.   +6 more
europepmc   +1 more source

Action potential duration alternans in mathematical models of excitable cells [PDF]

, 2017
Action potential duration alternans has been associated with the onset of one of the most common forms of abnormal heart rhythm, atrial fibrillation (Cherry et al., 2012; Nattel, 2002).
Asgari-Targhi, Ameneh
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Markedly prolonged compound muscle action potential duration in a patient with coronavirus disease 2019 related critical illness myopathy

, 2023
Yoshikazu Mizoi, Kei Ikeda, Masahiro Sonoo, Yuki Hatanaka, Toshimasa Yamamoto   +4 more
openalex   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source