Results 151 to 160 of about 12,692,953 (333)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
陆军军医大学学报Objective To investigate the effect of mmu_circ_0005019 on regulating Kcnn3 expression, small conductance calcium-activated potassium current (IK,Ca) which is generated by the small conductance calcium-activated potassium (SK) channel that is partly ...
YANG Lanqing, WU Na, CHEN Penghu
doaj +1 more source
Participatory action research and living theory action research in the Northern Territory
, 2013 This article is based on my honours thesis, ‘You or Me? A Social Framework in support of Indigenous community organisation’. It gives an overview of the reflective learning processes analysed in the thesis as I positioned myself as a community ...
Beattie, Michael
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
EMPOWERMENT IN PARTICIPATORY ACTION RESEARCH CONDUCTED IN MALAYSIA
, 2014 Participatory action research advocates participation and egalitarian relationship among its participants. This study was conducted in Malaysia amongst the Malay society, where the Malay society has been labelled as having high power distance in its ...
Puteh-Behak, Fariza
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
, 1994 The possibility that adenosine modulates voltage-dependent conductances in locus coeruleus neurons was investigated in current-clamp and voltage-clamp experiments in a totally submerged rat brain slice preparation.
SA Shefner, SS Osmanovic, WJ Pan
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Improving Indigenous Women’s Wellness Through Action Research
, 2013 This paper describes an action research project undertaken with Indigenous women in the highly urbanised area of north Brisbane. The project was a collaborative effort to move beyond the alarming statistics of Indigenous women’s poor health status.
Walker, Melissa +2 more
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source