Results 51 to 60 of about 13,265,348 (295)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements

Frontiers in Physiology
Measurement of the ventricular action potential (AP) via whole-cell patch clamp is an important contributor to cardiac electrophysiological research. Neonatal rat ventricular cardiomyocytes (NRVCM) are a commonly used model, in particular for stressor ...
Pascal Syren, Pascal Syren, Pascal Syren, Anna Zlatopolskaia, Anna Zlatopolskaia, Anna Zlatopolskaia, Claus Bruehl, Axel Schöffel, Axel Schöffel, Axel Schöffel, Teresa Caspari, Teresa Caspari, Teresa Caspari, Chiara Heß, Chiara Heß, Chiara Heß, Norbert Frey, Norbert Frey, Norbert Frey, Dierk Thomas, Dierk Thomas, Dierk Thomas, Patrick Lugenbiel, Patrick Lugenbiel, Patrick Lugenbiel   +24 more
doaj   +1 more source

The Venom of Ornithoctonus huwena affect the electrophysiological stability of neonatal rat ventricular myocytes by inhibiting sodium, potassium and calcium current

Channels, 2018
Spider venoms are known to contain various toxins that are used as an effective means to capture their prey or to defend themselves against predators. An investigation of the properties of Ornithoctonus huwena (O.huwena) crude venom found that the venom ...
Sha Yan, Pengfei Huang, Ying Wang, Xiongzhi Zeng, Yiya Zhang   +4 more
doaj   +1 more source

Postrest Shortening of the Action Potential Duration in Rabbits

Japanese Circulation Journal, 1998
Previous evidence has shown that the action potential duration of rabbit ventricular muscle cells shortens after a rest period (postrest shortening). However, there has not been much research on postrest shortening in the intact heart. We recorded transmembrane action potentials (TAPs) of isolated papillary muscle from rabbit ventricle with glass ...
Ishida, Shuji, Takahashi, Naohiko, Saikawa, Tetsunori, Iwao, Tetsu, Fujino, Takao, Nakagawa, Mikiko, Yonemochi, Hidetoshi, Ito, Morio   +7 more
openaire   +3 more sources

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

The Relationship between Frequency Dependence of Action Potential Duration and the Expression of TRPC3 in Rabbit Ventricular Myocardium

Cellular Physiology and Biochemistry, 2014
Background/Aims: Cardiac action potential duration (APD) is regulated by heart rate, leading to the trans-membrane movement of inorganic ions. Whether the alteration of heart rate can affect the expression of transient receptor potential canonical ...
Yong Wang, Mo-Si Chen, Hong-Chang Liu, Jun-Hua Xiao, Jia-Ling Wang   +4 more
doaj   +1 more source

Action potential duration in ventricular muscle during selective metabolic block

, 1987
We have examined whether maintenance of the cardiac action potential duration depends exclusively on energy from glycolysis. Oxidative phosphorylation in guinea pig papillary muscles was inhibited by superfusion with hypoxic solutions.
T. F. McDonald, T. Watanabe, H. Hayashi
core   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

Human Ventricular Action Potential Duration Restitution

Journal of the American College of Cardiology, 2008
We read with interest the paper by Narayan et al. ([1][1]) that related right ventricular (RV) action potential duration (APD) restitution slopes to the presence of T-wave alternans (TWA) and ventricular tachycardia (VT) inducibility in patients with left ventricular (LV) dysfunction (LV ...
Selvaraj, Raja J., Chauhan, Vijay S.
openaire   +1 more source

Shortening of cardiac action potential duration near an insulating boundary [PDF]

Mathematical Medicine and Biology, 2008
It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre.
John W, Cain, David G, Schaeffer
openaire   +2 more sources