Results 51 to 60 of about 12,692,953 (333)

Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator

Frontiers in Physiology, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Michael A. Colman, Erick A. Perez Alday, Arun V. Holden, Alan P. Benson   +3 more
doaj   +1 more source

Shortening of cardiac action potential duration near an insulating boundary [PDF]

Mathematical Medicine and Biology, 2008
It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre.
John W, Cain, David G, Schaeffer
openaire   +2 more sources

Ionic and Electrotonic Contributions to Short-Term Ventricular Action Potential Memory: An In Silico Study

Computation
Electrical restitution (ER) is a determinant of cardiac repolarization stability and can be measured as steady action potential (AP) duration (APD) at different pacing rates—the so-called dynamic restitution (ERdyn) curve—or as APD changes after pre- or ...
Massimiliano Zaniboni
doaj   +1 more source

Effects of antiarrhythmics on the electrical restitution in perfused guinea‐pig heart are critically determined by the applied cardiac pacing protocol

Experimental Physiology, 2019
New Findings What is the central question of this study? Are modifications in the restitution of ventricular action potential duration induced by antiarrhythmic drugs the same when assessed with premature extrastimulus application at variable coupling ...
Oleg E. Osadchii
doaj   +1 more source

Contraction force versus action potential duration of cardiomyocytes: which methodology is more informative for selection of effective 1,4-dihydropyridine compounds in experimental research?

Acta Medica Lituanica, 2015
Background. Identification of activity properties of new synthesized compounds is important to help choose the adequate research methodology. The goal of this experimental research was to determine the relationship between the chemical structure of 25 ...
Vygantas Barsys, Vida Garalienė, Gediminas Urbonas   +2 more
doaj   +1 more source

Intra-Individual Comparison of Sinus and Ectopic Beats Probing the Ventricular Gradient’s Activation Dependence

Journal of Cardiovascular Development and Disease, 2023
Wilson assumed that the ventricular gradient (VG) is independent of the ventricular activation order. This paradigm has often been refuted and was never convincingly corroborated.
Resi M. Schoonderwoerd, Mariëlle Dik, Sumche Man, Arie C. Maan, J. Wouter Jukema, Cees A. Swenne   +5 more
doaj   +1 more source

The Relationship between Frequency Dependence of Action Potential Duration and the Expression of TRPC3 in Rabbit Ventricular Myocardium

Cellular Physiology and Biochemistry, 2014
Background/Aims: Cardiac action potential duration (APD) is regulated by heart rate, leading to the trans-membrane movement of inorganic ions. Whether the alteration of heart rate can affect the expression of transient receptor potential canonical ...
Yong Wang, Mo-Si Chen, Hong-Chang Liu, Jun-Hua Xiao, Jia-Ling Wang   +4 more
doaj   +1 more source

Action Potential Duration-Stabilizing Action of Taurine in Guinea Pig Ventricular Myocytes

Japanese Journal of Pharmacology, 1996
To examine taurine actions on the rate of repolarization of action potentials (AP), L-type Ca2+ (ICa), late outward K+ (Ik) and the inward rectifier currents as affected by the external Ca2+ concentrations ([Ca2+]o), whole-cell voltage-clamp and current-clamp experiments were conducted in guinea pig ventricular myocytes.
Sada, Hideaki, Ban, Takashi, Sperelakis, Nicholas   +2 more
openaire   +3 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Fibroblast Growth Factor 21 Ameliorates NaV1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes

Frontiers in Pharmacology, 2021
Infarcted myocardium is predisposed to cause lethal ventricular arrhythmias that remain the main cause of death in patients suffering myocardial ischemia. Liver-derived fibroblast growth factor 21 (FGF21) is an endocrine regulator, which exerts metabolic
Jiamin Li, Jiamin Li, Yuanshi Li, Yining Liu, Yining Liu, Hang Yu, Hang Yu, Ning Xu, Ning Xu, Di Huang, Di Huang, Yadong Xue, Yadong Xue, Sijia Li, Sijia Li, Haixin Chen, Haixin Chen, Jiali Liu, Jiali Liu, Qingsui Li, Qingsui Li, Yiming Zhao, Yiming Zhao, Ronghao Zhang, Ronghao Zhang, Hongru Xue, Hongru Xue, Yuehang Sun, Yuehang Sun, Ming Li, Ming Li, Pengyu Li, Pengyu Li, Mingbin Liu, Mingbin Liu, Zhen Zhang, Zhen Zhang, Xin Li, Xin Li, Weijie Du, Weijie Du, Ning Wang, Ning Wang, Baofeng Yang, Baofeng Yang   +44 more
doaj   +1 more source