Results 31 to 40 of about 13,265,348 (295)

Incorrectly corrected? QT interval analysis in rats and mice

Frontiers in Physiology, 2022
QT interval, a surrogate measure for ventricular action potential duration (APD) in the surface ECG, is widely used to identify cardiac abnormalities and drug safety.
Wesam Mulla, Wesam Mulla, Michael Murninkas, Michael Murninkas, Or Levi, Or Levi, Yoram Etzion, Yoram Etzion   +7 more
doaj   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core   +1 more source

Relationship Between Electrical Instability and Pumping Performance During Ventricular Tachyarrhythmia: Computational Study

Frontiers in Physiology, 2020
There are representative electrical parameters for understanding the mechanism of reentrant waves in studies on tachyarrhythmia, namely the action potential duration (APD), dominant frequency, phase singularity, and filament.
Da Un Jeong, Ki Moo Lim
doaj   +1 more source

Sex‐specific repolarization heterogeneity in mouse left ventricle: Optical mapping combined with mathematical modeling predict the contribution of specific ionic currents

Physiological Reports, 2023
Ventricular repolarization shows notable sex‐specificity, with female sex being associated with longer QT‐intervals in electrocardiography irrespective of the species studied.
S. Erfan Moussavi‐Torshizi, Ehsan Amin, Nikolaj Klöcker   +2 more
doaj   +1 more source

Comparative Pharmacodynamics of Three Different Botulinum Toxin Type A Preparations following Repeated Intramuscular Administration in Mice

Toxins, 2022
Botulinum neurotoxin type A (BoNT/A) causes muscle paralysis by blocking cholinergic signaling at neuromuscular junctions and is widely used to temporarily correct spasticity-related disorders and deformities.
Jaeyoon Byun, Seongsung Kwak, Jin-Hee Kwon, Minhee Shin, Dong-Kyu Lee, Chang-Hoon Rhee, Won-ho Kang, Jae-Wook Oh, Deu John M. Cruz   +8 more
doaj   +1 more source

Characterization of the Electrophysiologic Remodeling of Patients With Ischemic Cardiomyopathy by Clinical Measurements and Computer Simulations Coupled With Machine Learning

Frontiers in Physiology, 2021
RationalePatients with ischemic cardiomyopathy (ICMP) are at high risk for malignant arrhythmias, largely due to electrophysiological remodeling of the non-infarcted myocardium.
Konstantinos N. Aronis, Konstantinos N. Aronis, Adityo Prakosa, Teya Bergamaschi, Ronald D. Berger, Patrick M. Boyle, Jonathan Chrispin, Suyeon Ju, Joseph E. Marine, Sunil Sinha, Harikrishna Tandri, Hiroshi Ashikaga, Natalia A. Trayanova, Natalia A. Trayanova   +13 more
doaj   +1 more source

Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator

Frontiers in Physiology, 2017
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia.
Michael A. Colman, Erick A. Perez Alday, Arun V. Holden, Alan P. Benson   +3 more
doaj   +1 more source

Ionic and Electrotonic Contributions to Short-Term Ventricular Action Potential Memory: An In Silico Study

Computation
Electrical restitution (ER) is a determinant of cardiac repolarization stability and can be measured as steady action potential (AP) duration (APD) at different pacing rates—the so-called dynamic restitution (ERdyn) curve—or as APD changes after pre- or ...
Massimiliano Zaniboni
doaj   +1 more source

Effects of antiarrhythmics on the electrical restitution in perfused guinea‐pig heart are critically determined by the applied cardiac pacing protocol

Experimental Physiology, 2019
New Findings What is the central question of this study? Are modifications in the restitution of ventricular action potential duration induced by antiarrhythmic drugs the same when assessed with premature extrastimulus application at variable coupling ...
Oleg E. Osadchii
doaj   +1 more source

α1-adrenergic stimulation increases ventricular action potential duration in the intact mouse heart

FACETS, 2021
The role of α1-adrenergic receptors (α-ARs) in the regulation of myocardial function is less well-understood than that of β-ARs. Previous reports in the mouse heart have described that α1-adrenergic stimulation shortens action potential duration in ...
William Joyce, Koen T. Scholman, Bjarke Jensen, Tobias Wang, Bastiaan J. Boukens   +4 more
doaj   +1 more source