Results 31 to 40 of about 12,692,953 (333)

Interleukin-6 Elevation Is a Key Pathogenic Factor Underlying COVID-19-Associated Heart Rate-Corrected QT Interval Prolongation

Frontiers in Cardiovascular Medicine, 2022
BackgroundHeart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes.
Pietro Enea Lazzerini, Riccardo Accioli, Maurizio Acampa, Wen-Hui Zhang, Wen-Hui Zhang, Decoroso Verrengia, Alessandra Cartocci, Maria Romana Bacarelli, Xiaofeng Xin, Viola Salvini, Ke-Su Chen, Fabio Salvadori, Antonio D’errico, Stefania Bisogno, Gabriele Cevenini, Tommaso Marzotti, Matteo Capecchi, Franco Laghi-Pasini, Long Chen, Pier Leopoldo Capecchi, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +22 more
doaj   +1 more source

Myocardial remodeling and bioelectric changes in tachycardia-induced heart failure in dogs

Brazilian Journal of Medical and Biological Research, 2013
In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that ...
B. Song, B.N. Wang, D.N. Chen, Z.G. Luo
doaj   +1 more source

Rate-dependency of action potential duration and refractoriness in isolated myocytes from the rabbit AV node and atrium [PDF]

, 2000
During atrial fibrillation, ventricular rate is determined by atrioventricular nodal (AVN) conduction, which in part is dependent upon the refractoriness of single AVN cells.
Kane, K.A., Rankin, A.C., Workman, A.J.
core   +1 more source

Acetylcholine Reduces I_Kr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes

Biomedicines, 2022
Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed.
István Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov   +10 more
doaj   +1 more source

Drug-induced changes in action potential duration are proportional to action potential duration in rat ventricular myocardium

General Physiology and Biophysics, 2010
Several cardioactive agents exhibit direct or reverse rate-dependent effects on action potential duration (APD) depending on the experimental conditions. Recently, a new theory has been proposed, suggesting that the reverse rate-dependent mode of drug-action may be a common property of canine, rabbit, guinea pig and human cardiac tissues, and this ...
László, Bárándi, Gábor, Harmati, Balázs, Horváth, Norbert, Szentandrássy, János, Magyar, András, Varró, Péter P, Nánási, Tamás, Bányász   +7 more
openaire   +3 more sources

The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes [PDF]

, 2016
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and higher throughput platforms have emerged as potential tools to advance cardiac drug safety screening.
Zamora, V., Burton, F.L., Smith, G.L., Green, J., Gintant, G.A., Hortigon-Vinagre, M.P.   +5 more
core   +1 more source

Effects of Oxypeucedanin on hKv1.5 and Action Potential Duration

Biological and Pharmaceutical Bulletin, 2005
A furocoumarin derivative, oxypeucedanin, was purified from Angelica dahurica, and its effects on the human Kv1.5 (hKv1.5) channel and on the cardiac action potential duration (APD), were examined using the patch-clamp technique and the conventional microelectrode technique. Oxypeucedanin inhibited the hKv1.5 current in a concentration-dependent manner,
Eun, Jae Soon, Park, Jung Ah, Choi, Bok Hee, Cho, Sun Kyung, Kim, Dae Keun, Kwak, Yong Geun   +5 more
openaire   +3 more sources

Depolarization and Action Potential Duration in Cardiac Purkinje Fibers [PDF]

Circulation Research, 1973
The effect of depolarization on the duration of the action potential was studied in short cardiac Purkinje fibers. Membrane potential was altered by overdriving pacemaker fibers showing spontaneous diastolic depolarization (dog), by injecting constantcurrent pulses through an intracellular microelectrode (sheep), or by voltage clamping (dog).
ARITA, MAKOTO, SURAWICZ, BORYS
openaire   +3 more sources

Pathological prolongation of action potential duration as a cause of the reduced alpha-adrenoceptor-mediated negative inotropy in streptozotocin-induced diabetic mice myocardium

Journal of Pharmacological Sciences, 2017
Effect of pathological prolongation of action potential duration on the α-adrenoceptor-mediated negative inotropy was studied in streptozotocin-induced diabetic mice myocardium.
Haruna Kanae, Shogo Hamaguchi, Yumi Wakasugi, Taichi Kusakabe, Keisuke Kato, Iyuki Namekata, Hikaru Tanaka   +6 more
doaj   +1 more source

Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic [PDF]

Circulation, 2001
Background—Prolongation of action potential duration (APD) is considered a major antiarrhythmic mechanism (class 2I), but paradoxically, it frequently is also proarrhythmic (torsade de pointes).Methods and Results—The cardiac electrophysiological effects of 702 chemicals (class 2I or HERG channel block) were studied in 1071 rabbit Langendorff-perfused ...
L M, Hondeghem, L, Carlsson, G, Duker
openaire   +2 more sources