Results 21 to 30 of about 12,692,953 (333)

Correction: Kovács et al. ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of I_Kr. Pharmaceuticals 2023, 16, 488. [PDF]

Pharmaceuticals (Basel)
Kovács ZM, Óvári J, Dienes C, Magyar J, Bányász T, Nánási PP, Horváth B, Feher A, Varga Z, Szentandrássy N.   +9 more
europepmc   +3 more sources

Mechanisms and determinants of ultralong action potential duration and slow rate-dependence in cardiac myocytes. [PDF]

PLoS ONE, 2012
In normal cardiac myocytes, the action potential duration (APD) is several hundred milliseconds. However, experimental studies showed that under certain conditions, APD could be excessively long (or ultralong), up to several seconds.
Zhilin Qu, Douglas Chung
doaj   +2 more sources

The entrainment of action potential duration and contraction amplitude by recapitulation of respiratory sinus arrhythmia in isolated cardiac myocytes [PDF]

Europace
Alexander Carpenter, Laura Pannell, Ewan Douglas Fowler, Andrew S. Butler, Julian Francis Richmond Paton, Jules C. Hancox, Andrew F. James   +6 more
europepmc   +3 more sources

Comparison of in silico predictions of action potential duration in response to inhibition of I _Kr and I _CaL with new human ex vivo recordings

Barral YH, Polonchuk L, Clerx M, Gavaghan DJ, Mirams GR, Wang K.   +5 more
europepmc   +2 more sources

Sensitivity Analysis of Ion Channel Conductance on Myocardial Electromechanical Delay: Computational Study

Frontiers in Physiology, 2021
It is well known that cardiac electromechanical delay (EMD) can cause dyssynchronous heart failure (DHF), a prominent cardiovascular disease (CVD). This work computationally assesses the conductance variation of every ion channel on the cardiac cell to ...
Ali Ikhsanul Qauli, Aroli Marcellinus, Ki Moo Lim   +2 more
doaj   +1 more source

Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification

Frontiers in Cardiovascular Medicine, 2021
Reentrant cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF) are common cardiac arrhythmias that account for substantial morbidity and mortality throughout the world.
Uma Mahesh R. Avula, Lea Melki, Jared S. Kushner, Stephanie Liang, Elaine Y. Wan   +4 more
doaj   +1 more source

Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy

Clinical and Translational Medicine, 2021
Background Severe ventricular rhythm disturbances are the hallmark of arrhythmogenic cardiomyopathy (ACM), and are often explained by structural conduction abnormalities.
Adrien Moreau, Jean‐Baptiste Reisqs, Helene Delanoe‐Ayari, Marion Pierre, Alexandre Janin, Antoine Deliniere, Francis Bessière, Albano C. Meli, Azzouz Charrabi, Estele Lafont, Camille Valla, Delphine Bauer, Elodie Morel, Vincent Gache, Gilles Millat, Xavier Nissan, Adele Faucherre, Chris Jopling, Sylvain Richard, Alexandre Mejat, Philippe Chevalier   +20 more
doaj   +1 more source

Measures of repolarization variability predict ventricular arrhythmogenesis in heptanol-treated Langendorff-perfused mouse hearts

Current Research in Physiology, 2021
Background: Time-domain and non-linear methods can be used to quantify beat-to-beat repolarization variability but whether measures of repolarization variability can predict ventricular arrhythmogenesis in mice have never been explored.
Gary Tse, Guoliang Hao, Sharen Lee, Jiandong Zhou, Qingpeng Zhang, Yimei Du, Tong Liu, Shuk Han Cheng, Wing Tak Wong   +8 more
doaj   +1 more source

The ‘Reverse FDUF’ Mechanism of Atrial Excitation–Contraction Coupling Sustains Calcium Alternans—A Hypothesis

Biomolecules, 2022
Cardiac calcium alternans is defined as beat-to-beat alternations of Ca transient (CaT) amplitude and has been linked to cardiac arrhythmia, including atrial fibrillation.
Kathrin Banach, Lothar A. Blatter
doaj   +1 more source

Deterministic and Stochastic Cellular Mechanisms Contributing to Carbon Monoxide Induced Ventricular Arrhythmias

Frontiers in Pharmacology, 2021
Chronic exposure to low levels of Carbon Monoxide is associated with an increased risk of cardiac arrhythmia. Microelectrode recordings from rat and guinea pig single isolated ventricular myocytes exposed to CO releasing molecule CORM-2 and excited at 0 ...
Moza M. Al-Owais, Derek S. Steele, Arun V. Holden, Alan P. Benson   +3 more
doaj   +1 more source