MicroRNA-365 regulates human cardiac action potential duration [PDF]
Nature Communications, 2022 An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.
Dena Esfandyari +20 more
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Strategies for prolonging ventricular action potential duration without increasing transmural dispersion of repolarization [PDF]
Physiological ReportsDispersion of repolarization results from a non‐homogeneous recovery of excitability in cardiac tissue, and it is an important factor in arrhythmogenesis because it could lead to the initiation and maintenance of a variety of arrhythmias.
Candido Cabo
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The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study [PDF]
BioMedical Engineering OnLine, 2018 Background and aims Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac ...
Da Un Jeong, Ki Moo Lim
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Oscillatory behaviour of ventricular action potential duration in heart failure patients at respiratory rate and low frequency [PDF]
Frontiers in Physiology, 2014 Oscillations of arterial pressure occur spontaneously at a frequency of approx. 0.1Hz coupled with synchronous oscillations of sympathetic nerve activity (Mayer waves).
Ben eHanson +9 more
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Pro-Arrhythmic Ventricular Remodeling Is Associated With Increased Respiratory and Low-Frequency Oscillations of Monophasic Action Potential Duration in the Chronic Atrioventricular Block Dog Model [PDF]
Frontiers in Physiology, 2019 In addition to beat-to-beat fluctuations, action potential duration (APD) oscillates at (1) a respiratory frequency and (2) a low frequency (LF) (<0.1 Hz), probably caused by bursts of sympathetic nervous system discharge.
David Jaap Sprenkeler +4 more
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Heterogeneity of the action potential duration is required for sustained atrial fibrillation. [PDF]
JCI Insight, 2019 Atrial fibrillation (AF) is the most common cardiac arrhythmia and accounts for substantial morbidity and mortality. Recently, we created a mouse model with spontaneous and sustained AF caused by a mutation in the Na V 1.5 channel (F1759A) that enhances persistent Na +
Avula UMR +16 more
europepmc +4 more sources
Effect of Adrenergic Stimulation on Action Potential Duration Restitution in Humans [PDF]
Circulation, 2003 Background— Enhanced sympathetic activity facilitates complex ventricular arrhythmias and fibrillation. The restitution properties of action potential duration (APD) are important determinants of electrical stability in the myocardium.
Peter Taggart +2 more
exaly +3 more sources
ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of IKr. [PDF]
Pharmaceuticals (Basel), 2023 Kovács ZM +9 more
europepmc +3 more sources
α1-adrenergic stimulation increases ventricular action potential duration in the intact mouse heart
FACETS, 2021 The role of α1-adrenergic receptors (α-ARs) in the regulation of myocardial function is less well-understood than that of β-ARs. Previous reports in the mouse heart have described that α1-adrenergic stimulation shortens action potential duration in ...
William Joyce +4 more
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SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome. [PDF]
Heart Rhythm O2, 2023 Kim M +8 more
europepmc +2 more sources