Results 1 to 10 of about 13,265,348 (295)

MicroRNA-365 regulates human cardiac action potential duration [PDF]

Nature Communications, 2022
An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.
Dena Esfandyari, Bio Maria Ghéo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grüter, Melanie Annemarie Meier, Anna Christina Näger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt   +20 more
doaj   +8 more sources

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study [PDF]

BioMedical Engineering OnLine, 2018
Background and aims Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac ...
Da Un Jeong, Ki Moo Lim
doaj   +2 more sources

Pro-Arrhythmic Ventricular Remodeling Is Associated With Increased Respiratory and Low-Frequency Oscillations of Monophasic Action Potential Duration in the Chronic Atrioventricular Block Dog Model [PDF]

Frontiers in Physiology, 2019
In addition to beat-to-beat fluctuations, action potential duration (APD) oscillates at (1) a respiratory frequency and (2) a low frequency (LF) (<0.1 Hz), probably caused by bursts of sympathetic nervous system discharge.
David Jaap Sprenkeler, Jet D. M. Beekman, Alexandre Bossu, Albert Dunnink, Marc A. Vos   +4 more
doaj   +2 more sources

Oscillatory behaviour of ventricular action potential duration in heart failure patients at respiratory rate and low frequency [PDF]

Frontiers in Physiology, 2014
Oscillations of arterial pressure occur spontaneously at a frequency of approx. 0.1Hz coupled with synchronous oscillations of sympathetic nerve activity (Mayer waves).
Ben eHanson, Nick eChild, Stefan evan Duijvenboden, Michele eOrini, Zhong eChen, Ruben eCoronel, Christopher Aldo Rinaldi, Jaspal Singh Gill, Jaswinder Singh Gill, Peter eTaggart   +9 more
doaj   +2 more sources

Strategies for prolonging ventricular action potential duration without increasing transmural dispersion of repolarization [PDF]

Physiological Reports
Dispersion of repolarization results from a non‐homogeneous recovery of excitability in cardiac tissue, and it is an important factor in arrhythmogenesis because it could lead to the initiation and maintenance of a variety of arrhythmias.
Candido Cabo
doaj   +2 more sources

Heterogeneity of the action potential duration is required for sustained atrial fibrillation. [PDF]

JCI Insight, 2019
Atrial fibrillation (AF) is the most common cardiac arrhythmia and accounts for substantial morbidity and mortality. Recently, we created a mouse model with spontaneous and sustained AF caused by a mutation in the Na V 1.5 channel (F1759A) that enhances persistent Na +
Avula UMR, Abrams J, Katchman A, Zakharov S, Mironov S, Bayne J, Roybal D, Gorti A, Yang L, Iyer V, Waase M, Saluja D, Ciaccio EJ, Garan H, Marks AR, Marx SO, Wan EY.   +16 more
europepmc   +4 more sources

Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration [PDF]

Frontiers in Physiology, 2017
Background: Exaggerated beat-to-beat variability of ventricular action potential duration (APD) is linked to arrhythmogenesis. Sympathetic stimulation has been shown to increase QT interval variability, but its effect on ventricular APD in humans has not
Bradley Porter, Martin J. Bishop, Simon Claridge, Jonathan Behar, Benjamin J. Sieniewicz, Jessica Webb, Justin Gould, Mark O'Neill, Christopher A. Rinaldi, Reza Razavi, Jaswinder S. Gill, Peter Taggart   +11 more
doaj   +2 more sources

Action Potential Duration Restitution Kinetics in Human Atrial Fibrillation.

Journal of the American College of Cardiology, 2002
We undertook this study to determine whether human atrial fibrillation (AF) relates to steeply sloped action potential duration restitution (APDR) kinetics and whether the spatial nonuniformity of APDR promotes persistence of AF.A steeply sloped APDR curve is known to be an important determinant of the induction of more complex action potential ...
Byung-Soo Kim
exaly   +3 more sources

Sensitivity Analysis of Ion Channel Conductance on Myocardial Electromechanical Delay: Computational Study

Frontiers in Physiology, 2021
It is well known that cardiac electromechanical delay (EMD) can cause dyssynchronous heart failure (DHF), a prominent cardiovascular disease (CVD). This work computationally assesses the conductance variation of every ion channel on the cardiac cell to ...
Ali Ikhsanul Qauli, Aroli Marcellinus, Ki Moo Lim   +2 more
doaj   +1 more source

Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification

Frontiers in Cardiovascular Medicine, 2021
Reentrant cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF) are common cardiac arrhythmias that account for substantial morbidity and mortality throughout the world.
Uma Mahesh R. Avula, Lea Melki, Jared S. Kushner, Stephanie Liang, Elaine Y. Wan   +4 more
doaj   +1 more source