Results 11 to 20 of about 12,692,953 (333)

Action potential duration restitution kinetics in human atrial fibrillation

Journal of the American College of Cardiology, 2002
We undertook this study to determine whether human atrial fibrillation (AF) relates to steeply sloped action potential duration restitution (APDR) kinetics and whether the spatial nonuniformity of APDR promotes persistence of AF.A steeply sloped APDR curve is known to be an important determinant of the induction of more complex action potential ...
Kim Byung-Soo, Gyo-Seung Hwang
exaly   +3 more sources

Beneficial action potential duration-shortening effects, but deleterious negative inotropism of IKs-activator docosahexaenoyl glycine in long QT syndrome type 2. [PDF]

Europace
Louradour J, Hornyik T, De la Cruz A, Hiniesto-Iñigo I, Alerni N, Barbieri M, Lopez R, Perez-Feliz S, Matas L, Nimani S, Giammarino L, Koren G, Zehender M, Brunner M, Liin SI, Larsson HP, Odening KE.   +16 more
europepmc   +3 more sources

Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration [PDF]

Frontiers in Physiology, 2017
Background: Exaggerated beat-to-beat variability of ventricular action potential duration (APD) is linked to arrhythmogenesis. Sympathetic stimulation has been shown to increase QT interval variability, but its effect on ventricular APD in humans has not
Bradley Porter, Martin J. Bishop, Simon Claridge, Jonathan Behar, Benjamin J. Sieniewicz, Jessica Webb, Justin Gould, Mark O'Neill, Christopher A. Rinaldi, Reza Razavi, Jaswinder S. Gill, Peter Taggart   +11 more
doaj   +2 more sources

Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings. [PDF]

PLoS Comput Biol
Barral YHM, Polonchuk L, Clerx M, Gavaghan DJ, Mirams GR, Wang K.   +5 more
europepmc   +3 more sources

Testosterone does not shorten action potential duration in Langendorff-perfused rabbit ventricles. [PDF]

Heart Rhythm, 2022
Ueoka A, Sung YL, Liu X, Rosenberg C, Chen Z, Everett TH, Rubart M, Tisdale JE, Chen PS.   +8 more
europepmc   +2 more sources

Ventricular arrhythmogenic remodelling in diet-induced metabolic syndrome driven by right-to-left regional differences in action potential duration and dominant frequency gradients. [PDF]

J Physiol
Arias-Mutis ÓJ, Calvo CJ, Bizy A, Ortiz-Guzmán JE, Such-Miquel L, Such L, Alberola A, Zhao J, Chorro FJ, Zarzoso M.   +9 more
europepmc   +2 more sources

Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether-à-go-go-Related Gene and Cav1.2. [PDF]

Front Pharmacol, 2022
Zheng Z, Cai D, Fu Y, Wang Y, Song Y, Lian J.   +5 more
europepmc   +3 more sources

Atria Selective Prolongation by NIP-142, an Antiarrhythmic Agent, of Refractory Period and Action Potential Duration in Guinea Pig Myocardium

Journal of Pharmacological Sciences, 2005
NIP-142 is a novel benzopyran compound that was shown to prolong the atrial effective refractory period and terminate experimental atrial fibrillation in the dog.
Tomoyuki Matsuda, Kentaro Takeda, Mie Ito, Reiko Yamagishi, Miku Tamura, Hideki Nakamura, Noriko Tsuruoka, Tomoaki Saito, Haruko Masumiya, Takeshi Suzuki, Naoko Iida-Tanaka, Maho Itokawa-Matsuda, Toru Yamashita, Nobutomo Tsuruzoe, Hikaru Tanaka, Koki Shigenobu   +15 more
doaj   +3 more sources

Sequence-Dependent Repolarization Is Modulated by Endogenous Action Potential Duration Gradients Rather Than Electrical Coupling in Ventricular Myocardium. [PDF]

J Am Heart Assoc
Blair GA, Depman M, Adams WP, Maisonneuve RO, Hoeker GS, Weinberg SH, Poelzing S.   +6 more
europepmc   +2 more sources

Impaired Cardiac AMPK (5'-Adenosine Monophosphate-Activated Protein Kinase) and Ca²⁺-Handling, and Action Potential Duration Heterogeneity in Ibrutinib-Induced Ventricular Arrhythmia Vulnerability. [PDF]

J Am Heart Assoc
Zhao Y, Du B, Chakraborty P, Denham N, Massé S, Lai PFH, Azam MA, Billia F, Thavendiranathan P, Abdel-Qadir H, Lopaschuk GD, Nanthakumar K.   +11 more
europepmc   +2 more sources