Results 11 to 20 of about 13,265,348 (295)

Pathological prolongation of action potential duration as a cause of the reduced alpha-adrenoceptor-mediated negative inotropy in streptozotocin-induced diabetic mice myocardium

Journal of Pharmacological Sciences, 2017
Effect of pathological prolongation of action potential duration on the α-adrenoceptor-mediated negative inotropy was studied in streptozotocin-induced diabetic mice myocardium.
Haruna Kanae, Shogo Hamaguchi, Yumi Wakasugi, Taichi Kusakabe, Keisuke Kato, Iyuki Namekata, Hikaru Tanaka   +6 more
doaj   +2 more sources

Monophasic action potential duration alternans after abrupt shortening of the cardiac cycle in humans

Journal of Arrhythmia, 2014
Background: Action potential alternans may be important in causing ventricular arrhythmias. Methods and results: We recorded monophasic action potentials from the right ventricular endocardium in patients with persistent atrial fibrillation who underwent
Kazumasa Sonoda, MD, Ichiro Watanabe, MD, Yasuo Okumura, MD, Naoko Sasaki, MD, Rikitake Kogawa, MD, Keiko Takahashi, MD, Hiroaki Mano, MD, Masayoshi Kofune, MD, Kimie Ohkubo, MD, Toshiko Nakai, MD, Satoshi Kunimoto, MD, Atsushi Hirayama, MD   +11 more
doaj   +2 more sources

Atria Selective Prolongation by NIP-142, an Antiarrhythmic Agent, of Refractory Period and Action Potential Duration in Guinea Pig Myocardium

Journal of Pharmacological Sciences, 2005
NIP-142 is a novel benzopyran compound that was shown to prolong the atrial effective refractory period and terminate experimental atrial fibrillation in the dog.
Tomoyuki Matsuda, Kentaro Takeda, Mie Ito, Reiko Yamagishi, Miku Tamura, Hideki Nakamura, Noriko Tsuruoka, Tomoaki Saito, Haruko Masumiya, Takeshi Suzuki, Naoko Iida-Tanaka, Maho Itokawa-Matsuda, Toru Yamashita, Nobutomo Tsuruzoe, Hikaru Tanaka, Koki Shigenobu   +15 more
doaj   +2 more sources

Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy

Clinical and Translational Medicine, 2021
Background Severe ventricular rhythm disturbances are the hallmark of arrhythmogenic cardiomyopathy (ACM), and are often explained by structural conduction abnormalities.
Adrien Moreau, Jean‐Baptiste Reisqs, Helene Delanoe‐Ayari, Marion Pierre, Alexandre Janin, Antoine Deliniere, Francis Bessière, Albano C. Meli, Azzouz Charrabi, Estele Lafont, Camille Valla, Delphine Bauer, Elodie Morel, Vincent Gache, Gilles Millat, Xavier Nissan, Adele Faucherre, Chris Jopling, Sylvain Richard, Alexandre Mejat, Philippe Chevalier   +20 more
doaj   +1 more source

Measures of repolarization variability predict ventricular arrhythmogenesis in heptanol-treated Langendorff-perfused mouse hearts

Current Research in Physiology, 2021
Background: Time-domain and non-linear methods can be used to quantify beat-to-beat repolarization variability but whether measures of repolarization variability can predict ventricular arrhythmogenesis in mice have never been explored.
Gary Tse, Guoliang Hao, Sharen Lee, Jiandong Zhou, Qingpeng Zhang, Yimei Du, Tong Liu, Shuk Han Cheng, Wing Tak Wong   +8 more
doaj   +1 more source

The ‘Reverse FDUF’ Mechanism of Atrial Excitation–Contraction Coupling Sustains Calcium Alternans—A Hypothesis

Biomolecules, 2022
Cardiac calcium alternans is defined as beat-to-beat alternations of Ca transient (CaT) amplitude and has been linked to cardiac arrhythmia, including atrial fibrillation.
Kathrin Banach, Lothar A. Blatter
doaj   +1 more source

Deterministic and Stochastic Cellular Mechanisms Contributing to Carbon Monoxide Induced Ventricular Arrhythmias

Frontiers in Pharmacology, 2021
Chronic exposure to low levels of Carbon Monoxide is associated with an increased risk of cardiac arrhythmia. Microelectrode recordings from rat and guinea pig single isolated ventricular myocytes exposed to CO releasing molecule CORM-2 and excited at 0 ...
Moza M. Al-Owais, Derek S. Steele, Arun V. Holden, Alan P. Benson   +3 more
doaj   +1 more source

Interleukin-6 Elevation Is a Key Pathogenic Factor Underlying COVID-19-Associated Heart Rate-Corrected QT Interval Prolongation

Frontiers in Cardiovascular Medicine, 2022
BackgroundHeart rate-corrected QT interval (QTc) prolongation is prevalent in patients with severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes.
Pietro Enea Lazzerini, Riccardo Accioli, Maurizio Acampa, Wen-Hui Zhang, Wen-Hui Zhang, Decoroso Verrengia, Alessandra Cartocci, Maria Romana Bacarelli, Xiaofeng Xin, Viola Salvini, Ke-Su Chen, Fabio Salvadori, Antonio D’errico, Stefania Bisogno, Gabriele Cevenini, Tommaso Marzotti, Matteo Capecchi, Franco Laghi-Pasini, Long Chen, Pier Leopoldo Capecchi, Mohamed Boutjdir, Mohamed Boutjdir, Mohamed Boutjdir   +22 more
doaj   +1 more source

Myocardial remodeling and bioelectric changes in tachycardia-induced heart failure in dogs

Brazilian Journal of Medical and Biological Research, 2013
In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that ...
B. Song, B.N. Wang, D.N. Chen, Z.G. Luo
doaj   +1 more source

Acetylcholine Reduces I_Kr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes

Biomedicines, 2022
Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed.
István Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamás Árpádffy-Lovas, Tibor Magyar, Noémi Tóth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov   +10 more
doaj   +1 more source