Results 41 to 50 of about 13,265,348 (295)

Effect of Adrenergic Stimulation on Action Potential Duration Restitution in Humans [PDF]

Circulation, 2003
Background— Enhanced sympathetic activity facilitates complex ventricular arrhythmias and fibrillation. The restitution properties of action potential duration (APD) are important determinants of electrical stability in the myocardium.
Peter, Taggart, Peter, Sutton, Zaid, Chalabi, Mark R, Boyett, Ron, Simon, Donna, Elliott, Jaswinder S, Gill   +6 more
openaire   +2 more sources

Contraction force versus action potential duration of cardiomyocytes: which methodology is more informative for selection of effective 1,4-dihydropyridine compounds in experimental research?

Acta Medica Lituanica, 2015
Background. Identification of activity properties of new synthesized compounds is important to help choose the adequate research methodology. The goal of this experimental research was to determine the relationship between the chemical structure of 25 ...
Vygantas Barsys, Vida Garalienė, Gediminas Urbonas   +2 more
doaj   +1 more source

Intra-Individual Comparison of Sinus and Ectopic Beats Probing the Ventricular Gradient’s Activation Dependence

Journal of Cardiovascular Development and Disease, 2023
Wilson assumed that the ventricular gradient (VG) is independent of the ventricular activation order. This paradigm has often been refuted and was never convincingly corroborated.
Resi M. Schoonderwoerd, Mariëlle Dik, Sumche Man, Arie C. Maan, J. Wouter Jukema, Cees A. Swenne   +5 more
doaj   +1 more source

Action Potential Duration-Stabilizing Action of Taurine in Guinea Pig Ventricular Myocytes

Japanese Journal of Pharmacology, 1996
To examine taurine actions on the rate of repolarization of action potentials (AP), L-type Ca2+ (ICa), late outward K+ (Ik) and the inward rectifier currents as affected by the external Ca2+ concentrations ([Ca2+]o), whole-cell voltage-clamp and current-clamp experiments were conducted in guinea pig ventricular myocytes.
Sada, Hideaki, Ban, Takashi, Sperelakis, Nicholas   +2 more
openaire   +3 more sources

Action potential duration and capture at different cycle lengths.

, 2013
A, Action potential duration at 20%, 50%, 70% and 90% repolarization (ms; mean ± SEM). B, Typical example of action potentials as seen with optical mapping.
Marieke W. Veldkamp (388867), Rob B. Janssen (388870), Hanno L. Tan (215614), Diane Bakker (388868), Jacques M. T. de Bakker (350439), A. Dénise den Haan (388866), Geert J. J. Boink (388869)   +6 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Fibroblast Growth Factor 21 Ameliorates NaV1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes

Frontiers in Pharmacology, 2021
Infarcted myocardium is predisposed to cause lethal ventricular arrhythmias that remain the main cause of death in patients suffering myocardial ischemia. Liver-derived fibroblast growth factor 21 (FGF21) is an endocrine regulator, which exerts metabolic
Jiamin Li, Jiamin Li, Yuanshi Li, Yining Liu, Yining Liu, Hang Yu, Hang Yu, Ning Xu, Ning Xu, Di Huang, Di Huang, Yadong Xue, Yadong Xue, Sijia Li, Sijia Li, Haixin Chen, Haixin Chen, Jiali Liu, Jiali Liu, Qingsui Li, Qingsui Li, Yiming Zhao, Yiming Zhao, Ronghao Zhang, Ronghao Zhang, Hongru Xue, Hongru Xue, Yuehang Sun, Yuehang Sun, Ming Li, Ming Li, Pengyu Li, Pengyu Li, Mingbin Liu, Mingbin Liu, Zhen Zhang, Zhen Zhang, Xin Li, Xin Li, Weijie Du, Weijie Du, Ning Wang, Ning Wang, Baofeng Yang, Baofeng Yang   +44 more
doaj   +1 more source

Monophasic action potential duration (MAPD) data used for calibration of the Control ePoM.

, 2019
Monophasic action potential duration (MAPD) data used for calibration of the Control ePoM.
Blanca Rodríguez (7016159), Carlos A. Ledezma (7209716), Xin Zhou (54275), Vanessa Díaz-Zuccarini (4397986), P. J. Tan (7209719)   +4 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Acetylcholine Reduces L-Type Calcium Current without Major Changes in Repolarization of Canine and Human Purkinje and Ventricular Tissue

Biomedicines, 2022
Vagal nerve stimulation (VNS) holds a strong basis as a potentially effective treatment modality for chronic heart failure, which explains why a multicenter VNS study in heart failure with reduced ejection fraction is ongoing.
Arie O. Verkerk, Illés J. Doszpod, Isabella Mengarelli, Tibor Magyar, Alexandra Polyák, Bence Pászti, Igor R. Efimov, Ronald Wilders, István Koncz   +8 more
doaj   +1 more source