Results 41 to 50 of about 12,692,953 (333)

Heterogeneities in Ventricular Conduction Following Treatment with Heptanol: A Multi-Electrode Array Study in Langendorff-Perfused Mouse Hearts

Life, 2022
Background: Previous studies have associated slowed ventricular conduction with the arrhythmogenesis mediated by the gap junction and sodium channel inhibitor heptanol in mouse hearts.
Xiuming Dong, Gary Tse, Guoliang Hao, Yimei Du   +3 more
doaj   +1 more source

Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates [PDF]

, 2012
Patch clamp recordings of isolated ventricular myocytes frequently display a temporal variability in the action potential duration. Intercellular coupling through gap junctions has been shown to reduce such variability which may return as coupling is ...
Walmsley, John, J.M. Pitt−Francis, Pitt−Francis, J., John Walmsley, Kevin Burrage, Gary R. Mirams, Rodriguez, Blanca, G.R. Mirams, Pitt−Francis, Joe M., Burrage, K., J. Walmsley, Mirams, G.R., Rodriguez, B., Pitt−Francis, J.M., Pitt-Francis, Joe M., Mirams, Gary R., Joe M. Pitt−Francis, Burrage, Kevin, Walmsley, J., Mirams, G., K. Burrage, B. Rodriguez, Blanca Rodriguez   +22 more
core   +2 more sources

Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System

Frontiers in Physiology, 2020
BackgroundRecent clinical, experimental and modeling studies link oscillations of ventricular repolarization in the low frequency (LF) (approx. 0.1 Hz) to arrhythmogenesis.
Stefan Van Duijvenboden, Bradley Porter, Esther Pueyo, Esther Pueyo, David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Baldeep Sidhu, Justin Gould, Michele Orini, Martin J. Bishop, Ben Hanson, Pier Lambiase, Reza Razavi, Christopher A. Rinaldi, Jaswinder S. Gill, Peter Taggart   +15 more
doaj   +1 more source

Bone Marrow Cell Transplantation into the Heart is Not a Crucial Factor of Ventricular Fibrillation in a Rat Doxorubicin-Induced Cardiomyopathy Model

Journal of Arrhythmia, 2006
To verify the susceptibility of ventricle to arrhythmia after bone marrow mononuclear cell transplantation (BMMNCT), we measured ventricular fibrillation threshold (VFT) and monophasic action potential duration (MAYD90).
Masaki Hamamoto, MD, Shinji Tomita, MD PhD, Masashi Inagaki, MD PhD, Chikao Yutani, MD PhD, Seiji Yamashiro, MD MSc, Kenji Sunagawa, MD PhD, Takeshi Nakatani, MD PhD, Soichiro Kitamura, MD PhD   +7 more
doaj   +1 more source

Incorrectly corrected? QT interval analysis in rats and mice

Frontiers in Physiology, 2022
QT interval, a surrogate measure for ventricular action potential duration (APD) in the surface ECG, is widely used to identify cardiac abnormalities and drug safety.
Wesam Mulla, Wesam Mulla, Michael Murninkas, Michael Murninkas, Or Levi, Or Levi, Yoram Etzion, Yoram Etzion   +7 more
doaj   +1 more source

Relationship Between Electrical Instability and Pumping Performance During Ventricular Tachyarrhythmia: Computational Study

Frontiers in Physiology, 2020
There are representative electrical parameters for understanding the mechanism of reentrant waves in studies on tachyarrhythmia, namely the action potential duration (APD), dominant frequency, phase singularity, and filament.
Da Un Jeong, Ki Moo Lim
doaj   +1 more source

Sex‐specific repolarization heterogeneity in mouse left ventricle: Optical mapping combined with mathematical modeling predict the contribution of specific ionic currents

Physiological Reports, 2023
Ventricular repolarization shows notable sex‐specificity, with female sex being associated with longer QT‐intervals in electrocardiography irrespective of the species studied.
S. Erfan Moussavi‐Torshizi, Ehsan Amin, Nikolaj Klöcker   +2 more
doaj   +1 more source

Comparative Pharmacodynamics of Three Different Botulinum Toxin Type A Preparations following Repeated Intramuscular Administration in Mice

Toxins, 2022
Botulinum neurotoxin type A (BoNT/A) causes muscle paralysis by blocking cholinergic signaling at neuromuscular junctions and is widely used to temporarily correct spasticity-related disorders and deformities.
Jaeyoon Byun, Seongsung Kwak, Jin-Hee Kwon, Minhee Shin, Dong-Kyu Lee, Chang-Hoon Rhee, Won-ho Kang, Jae-Wook Oh, Deu John M. Cruz   +8 more
doaj   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core   +1 more source

Characterization of the Electrophysiologic Remodeling of Patients With Ischemic Cardiomyopathy by Clinical Measurements and Computer Simulations Coupled With Machine Learning

Frontiers in Physiology, 2021
RationalePatients with ischemic cardiomyopathy (ICMP) are at high risk for malignant arrhythmias, largely due to electrophysiological remodeling of the non-infarcted myocardium.
Konstantinos N. Aronis, Konstantinos N. Aronis, Adityo Prakosa, Teya Bergamaschi, Ronald D. Berger, Patrick M. Boyle, Jonathan Chrispin, Suyeon Ju, Joseph E. Marine, Sunil Sinha, Harikrishna Tandri, Hiroshi Ashikaga, Natalia A. Trayanova, Natalia A. Trayanova   +13 more
doaj   +1 more source