Results 21 to 30 of about 3,738,124 (301)

Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation

open access: yesClinical and Translational Medicine, 2021
Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac electrophysiological signals, such as action potentials, to maintain normal heart excitability and contraction.
Lulan Chen   +4 more
doaj   +1 more source

The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current

open access: yesBiomedicines, 2023
Anti-epileptic drugs (AEDs) are associated with increased risk of sudden cardiac death. To establish whether gabapentin, lamotrigine, levetiracetam, pregabalin, and valproic acid reduce the Nav1.5 current, we conducted whole-cell patch-clamp studies to ...
Lixia Jia, Arie O. Verkerk, Hanno L. Tan
doaj   +1 more source

Biophysics of Extracellular Action Potentials [PDF]

open access: yes, 2007
The goal of this thesis is to analyze the generation of single unit extracellular action potentials (EAPs), and to explore pertinent issues in the interpretation of EAP recordings.
Gold, Carl
core   +1 more source

Large and fast human pyramidal neurons associate with intelligence

open access: yeseLife, 2018
It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although grey matter thickness and activity of temporal and frontal cortical areas correlate with IQ scores, no direct evidence exists that links ...
Natalia A Goriounova   +15 more
doaj   +1 more source

Modulation of Functional Connectivity Between Dopamine Neurons of the Rat Ventral Tegmental Area in vitro

open access: yesFrontiers in Integrative Neuroscience, 2019
Micro Electrode Arrays were used to simultaneously record spontaneous extracellular action potentials from 10 to 30 dopamine neurons in acute brain slices from the lateral Ventral Tegmental Area (VTA) of the rat.
Luuk van der Velden   +3 more
doaj   +1 more source

Intraoperative Microelectrode Recordings in Substantia Nigra Pars Reticulata in Anesthetized Rats

open access: yesFrontiers in Neuroscience, 2020
The Substantia Nigra pars reticulata (SNr) is a promising target for deep brain stimulation (DBS) to treat the gait and postural disturbances in Parkinson’s disease (PD).
Hanyan Li, George C. McConnell
doaj   +1 more source

Estimation of Multiple Cardiac Cells’ Action Potentials From Extracellular Field Potentials

open access: yesVìsnik Nacìonalʹnogo Tehnìčnogo Unìversitetu Ukraïni Kììvsʹkij Polìtehnìčnij Ìnstitut: Serìâ Radìotehnìka, Radìoaparatobuduvannâ, 2023
Modern biomedical technologies use a combination of microelectrode array (MEA) systems and artificially grown cells to study disease mechanisms and test drug effects.
M. O. Shpotak   +3 more
doaj   +1 more source

Event-Related Brain Potentials for Goal-Related Power Grips [PDF]

open access: yes, 2013
Westerholz J, Schack T, Koester D. Event-Related Brain Potentials for Goal-Related Power Grips. PLoS ONE. 2013;8(7): e68501.Recent research has shown that neurophysiological activation during action planning depends on the orientation to initial or final
Jan Westerholz (429286)   +11 more
core   +1 more source

Effects of sugammadex and rocuronium on electro-mechanical activity of cardiac myocytes [PDF]

open access: yesKorean Journal of Anesthesiology
Background Sugammadex reverses the effects of steroidal neuromuscular-blocking agents, such as rocuronium, by encapsulating these agents. Its cardiovascular adverse effects include QTc prolongation, hypotension, bradycardia, atrioventricular block ...
Oguzhan Arun   +6 more
doaj   +1 more source

Repolarization Alternans and Ventricular Arrhythmia in a Repaired Tetralogy of Fallot Animal Model

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Ventricular arrhythmia is an important cause of late death in patients with repaired tetralogy of Fallot (rTOF). By using an rTOF canine model, we investigated the role of repolarization alternans and its electrophysiological mechanisms ...
Shuenn‐Nan Chiu   +8 more
doaj   +1 more source

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