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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source
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Actionness-Assisted Recognition of Actions

2015 IEEE International Conference on Computer Vision (ICCV), 2015
We elicit from a fundamental definition of action low-level attributes that can reveal agency and intentionality. These descriptors are mainly trajectory-based, measuring sudden changes, temporal synchrony, and repetitiveness. The actionness map can be used to localize actions in a way that is generic across action and agent types. Furthermore, it also
Ye Luo, Loong-Fah Cheong, An Tran
openaire   +1 more source

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