Results 61 to 70 of about 49,137 (244)

A Rare Case of Acquired Haemophilia A Following Sigmoid Adenocarcinoma: Case Report and Literature Review

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Acquired haemophilia A (AHA) is a rare complication of malignancy. We report a case of AHA secondary to colorectal cancer which presented as post‐operative bleeding, progressive activated partial thromboplastin time prolongation, precipitous factor VIII (FVIII) decline and inhibitor development.
Benjamin Reardon, Harini Haran, Jennifer Curnow   +2 more
wiley   +1 more source

Evaluation of anticoagulant and thrombolytic activity of Berberis orthobotrys in animal model

Bangladesh Journal of Pharmacology, 2018
Fundamental to this research was the evaluation of anticoagulant and thrombolytic potential of Berberis orthobotrys using clotting time, prothrombin time and activated partial thromboplastin time performed at 2.5, 5, 10% concentration.
. Alamgeer, Mahpara Tarar, Umme Habiba Hasan, Muhammad Saleem   +3 more
doaj   +1 more source

Initial V‐A ECMO Flow‐Index and Its Association With Inflammation, Organ Failure, and Outcomes

Artificial Organs, EarlyView.
Higher initial V‐A ECMO flow‐index was associated with greater shock severity and independently associated with multi‐organ failure. Early hemolysis may partly contribute to this association, particularly in eCPR patients, whereas no significant indirect effect through IL‐6 was observed.
Kostiantyn Kozakov, Zdenek Provaznik, Alois Philipp, Maik Foltan, Christian Schach, Sergey Vasin, Andreas Keyser, Leopold Rupprecht, Christof Schmid, Simon Schopka   +9 more
wiley   +1 more source

Clot waveform analysis of prolonged activated partial thromboplastin time in various disorders

Indian Journal of Pathology and Microbiology
Introduction: The prolongation in APTT reflects various disorders affecting the blood coagulation system. Automated coagulation analyzers such as ACL TOP, help in evaluating the clotting cascade by displaying clot reaction curves or waveforms. The fibrin
Apeksha Kadu, Ami M. Shah, Hansa Goswami
doaj   +1 more source

Establishing reference ranges and normal values for coagulation screening in healthy Indian male volunteers enrolled for a longitudinal study

Biomedical and Biotechnology Research Journal, 2019
Background: The study was designed for establishing reference ranges and normal values for coagulation screening in healthy Indian male volunteers.
Rehan Ahmed, Prosenjit Ganguli, Natwar Singh, Surinderpal Singh, Umesh Das Gupta, Yogesh K Jaiswal, Zahid Asharaf, Prasanna Reddy, Velu Nair   +8 more
doaj   +1 more source

Normal thromboelastography with a markedly prolonged activated partial thromboplastin time in severe prekallikrein deficiency: Implications for perioperative hemostatic assessment. [PDF]

Transfusion
Abstract Background Prekallikrein (PK) deficiency is a rare contact factor deficiency that can markedly prolong the activated partial thromboplastin time (aPTT) without a bleeding phenotype. Because viscoelastic hemostatic assays also rely on contact activation, their behavior in severe PK deficiency is relevant to perioperative evaluation of isolated ...
Jacobs JW, Matafonov A, Baxter PG, Cheng Q, Booth GS, Sharma D, Tillman BF, Gailani D.   +7 more
europepmc   +2 more sources

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Prolonged activated partial thromboplastin time in pediatric patients – an important diagnostic challenge

Pediatria Polska
Basic hemostasis tests are among the most frequently performed laboratory investigations in pediatric practice. Therapeutic decisions regarding a child are often based on the results of screening hemostatic tests, such as the activated partial ...
Aleksandra Zima, Joanna Zdziarska
doaj   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad, Elin Pålsson, Vladimir Lazarevic, Leila Naddi, Ola Borgquist, Lars Nilsson, Maria Adrian, Björn P. Bark, Thomas Kander   +8 more
wiley   +1 more source

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

European Journal of Haematology, EarlyView.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako, Fumiyo Komatsu, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada   +11 more
wiley   +1 more source