Results 81 to 90 of about 32,297 (224)

Functional Assessment of Platelet‐Derived Phospholipid Activity in Pooled Normal Plasmas by Low‐Phospholipid Thrombin Generation Assay and Its Impact on Lupus Anticoagulant Mixing Tests

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Pooled normal plasma (PNP) used for lupus anticoagulant (LA) mixing tests may carry platelet‐derived phospholipid (PL) activity introduced during freezing/lyophilization, potentially attenuating LA‐mediated prolongation of clotting times.
Osamu Kumano, Masato Matsuda, Mino Sakata, Osamu Maruyama   +3 more
wiley   +1 more source

Effects of Rutin and Hesperidin and Their Al(III) and Cu(II) Complexes on in Vitro Plasma Coagulation Assays

Molecules, 2011
Two flavonoids, rutin and hesperidin, were investigated in vitro for anticoagulant activity through coagulation tests: activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT).
Vesna Kuntić, Zorica Vujić, Ivana Filipović   +2 more
doaj   +1 more source

Normal thromboelastography with a markedly prolonged activated partial thromboplastin time in severe prekallikrein deficiency: Implications for perioperative hemostatic assessment. [PDF]

Transfusion
Abstract Background Prekallikrein (PK) deficiency is a rare contact factor deficiency that can markedly prolong the activated partial thromboplastin time (aPTT) without a bleeding phenotype. Because viscoelastic hemostatic assays also rely on contact activation, their behavior in severe PK deficiency is relevant to perioperative evaluation of isolated ...
Jacobs JW, Matafonov A, Baxter PG, Cheng Q, Booth GS, Sharma D, Tillman BF, Gailani D.   +7 more
europepmc   +2 more sources

WTAP‐mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy

Journal of Diabetes Investigation, EarlyView.
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen   +6 more
wiley   +1 more source

Case Report: Differential diagnosis and clinical management of isolated prolonged activated partial thromboplastin time

Frontiers in Immunology
An unexpected, isolated prolongation of activated partial thromboplastin time (APTT) frequently poses diagnostic challenges in coagulation laboratories. This article presents two patients exhibiting isolated prolonged APTT, one with significant bleeding ...
Lu Liu, Dongmei Guo
doaj   +1 more source

Anticoagulant activities of oleanolic acid via inhibition of tissue factor expressions [PDF]

BMB Reports, 2012
Oleanolic acid (OA), a triterpenoid known for its anti-inflammatoryand anti-cancer properties, is commonly present in severalmedicinal plants but its anticoagulant activities have not beenstudied.
Wonhwa Lee1,2,#, Eun-Ju Yang3,#, Sae-Kwang Ku4,#, Kyung-Sik Song1 & Jong-Sup Bae1,*
doaj  

Preoperative Medical Evaluation and Optimisation of Children and Adolescents With Cerebral Palsy (GMFCS IV and V) With Complex Medical Comorbidity Undergoing Lower Limb Orthopaedic Surgery: Results of a Combined Rehabilitation Orthopaedic Paediatric Service

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim To describe preoperative medical evaluation, optimisation and acute postoperative outcomes in children and adolescents with cerebral palsy (CP) undergoing lower limb orthopaedic surgery managed in a Combined Rehabilitation Orthopaedic Paediatric Service (CROPS). Methods A retrospective medical record review of children and adolescents with
Jennifer Armstrong, Emre Ilhan, Verity Pacey, Paula Bray, Matthias Axt, Jacqueline Dalby‐Payne   +5 more
wiley   +1 more source

The changes in the fibrinogen concentration and coagulation pathways in winter and summer in cattle [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2013
Fibrinogen is an important coagulation factor and a positive acute phase protein and its levels increases in cases of inflammation infection and stress. The present research was done to determine whether the fibrinogen concentration, prothrombin time (PT)
ameneh khoshvaghti
doaj  

Oral Soft Tissue Biopsy in Patients Receiving Direct Oral Anticoagulants: A Prospective Cohort Study on Bleeding Outcomes

Oral Diseases, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are the first‐line therapy for stroke prevention in non‐valvular atrial fibrillation and venous thromboembolism. While evidence supports their continuation during routine dental procedures such as tooth extractions, data on oral soft tissue biopsies remain limited.
Rossana Izzetti, Chiara Cinquini, Antonio Barone, Marco Nisi   +3 more
wiley   +1 more source

Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

Transfusion, EarlyView.
Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis or mortality. Design Prospective observational study of neonatal and pediatric ECMO patients from September 2016, until ...
Rebecca Barton, Suelyn Van Den Helm, Hui Ping Yaw, Chantal Attard, Graeme MacLaren, Vera Ignjatovic, Natasha Letunica, Vasiliki Karlaftis, Tengyi Cai, Amy Johansen, Derek Best, Roberto Chiletti, Yves d'Udekem, Jo McKittrick, Warwick Butt, Paul Monagle   +15 more
wiley   +1 more source