Results 71 to 80 of about 32,297 (224)

Perioperative discovery of KLKB1 c.451dupT mutation causing prekallikrein deficiency in a Saudi child: A case report of safe surgery despite isolated severe aPTT prolongation

Therapeutic Advances in Hematology
Prekallikrein deficiency, a rare autosomal recessive disorder, results in isolated prolongation of activated partial thromboplastin time (aPTT) without associated bleeding symptoms. This condition often complicates preoperative screenings and can lead to
Faisal A. Alghamdi, Khalid Alahmadi, Asim Alamri, Amr Elyas, Mohamed Elsaid   +4 more
doaj   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Establishment of intra- and inter-laboratory reference change values for coagulation tests: PT, INR, and aPTT

Romanian Journal of Laboratory Medicine
Coagulation assays such as prothrombin time (PT), international normalized ratio (INR), and activated partial thromboplastin time (aPTT) are widely used for patient monitoring.
Bildirici Mehmet Akif, Gülten Sedat
doaj   +1 more source

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su, Yao Wei, Cheng Liu, Yafei Gao, Xiaolong Ma, Yongxin Li, Rui Qiao   +6 more
wiley   +1 more source

Assessment of Thrombin Generation in Pediatric Patients on Extracorporeal Life Support: Impact of Bivalirudin and Other Anticoagulants

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Bivalirudin is an alternative anticoagulant to heparin and is widely used in pediatric extracorporeal life support (ECLS). Its activity is monitored using activated partial thromboplastin time (aPTT) and/or more specific tests such as plasma‐diluted thrombin time (dTT).
Vadim Kostousov, Karen Bruzdoski, Amir Navaei, Jun Teruya   +3 more
wiley   +1 more source

Massive carcinocythaemia during fulminant relapse of invasive lobular breast carcinoma

British Journal of Haematology, EarlyView.
Amina Djoudi, Roman Vion, Olivier Matray, Lucie Poisson, Cédric Paquin, Victor Bobée   +5 more
wiley   +1 more source

Performance Assessment of Staclot‐LA Assay on Fully Automated Coagulation Analyser for Lupus Anticoagulant Testing Using Internal and External Quality Controls

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction It is recommended to detect lupus anticoagulant (LA) using two phospholipid‐dependent clotting assays, including a LA‐sensitive activated partial‐thromboplastin‐time (aPTT). Among these reagents, Staclot‐LA assay is performed on a mixture of test and normal plasma with and without hexagonal phase phospholipids.
V. Siguret, G. Jourdi, S. Melicine, L. Goubeau, Q. Pomorski, B. Joly‐Laffargue, A. Stepanian, M. Delrue, C. Bon, P. Meijer, E. Curis   +10 more
wiley   +1 more source

Prolonged activated partial thromboplastin time in pediatric patients – an important diagnostic challenge

Pediatria Polska
Basic hemostasis tests are among the most frequently performed laboratory investigations in pediatric practice. Therapeutic decisions regarding a child are often based on the results of screening hemostatic tests, such as the activated partial ...
Aleksandra Zima, Joanna Zdziarska
doaj   +1 more source

Is It Time to Raise the Threshold for Critically Low Fibrinogen? Insights From a Retrospective, Consecutive‐Case Cohort Study of Low Fibrinogen due to Various Causes

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Fibrinogen deficiency is an important coagulation abnormality, with diverse causes. Methods A consecutive‐case cohort study of adult and pediatric patients with low Clauss fibrinogen at four acute care hospitals was undertaken to explore findings, causes, and predictors of outcomes, including the optimal fibrinogen critical value ...
Natalie Mathews, Subia Tasneem, Mana Al Dawsari, Keona Pang, Yasmeen Abulkhair, Guillame Paré, Siraj Mithoowani, Catherine P. M. Hayward   +7 more
wiley   +1 more source

Diabetes mellitus is associated with shortened activated partial thromboplastin time and increased fibrinogen values.

PLoS ONE, 2011
ObjectiveThis study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus.MethodsAPTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG)
Ying Zhao, Jie Zhang, Juanwen Zhang, Jianping Wu   +3 more
doaj   +1 more source