Results 61 to 70 of about 122,624 (309)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Circulating B-cell activating Factor in Multiple Myeloma Patients and its Correlations with Serum Levels of β2-Microglobulin and Interleukin-6

مجلة كلية الطب
Background: Multiple myeloma (MM) is characterized by clonal proliferation of malignant plasma cells within the bone marrow. In most patients, monoclonal immunoglobulin heavy chains or light chains are produced and are associated with organ dysfunction.
Wafaa F. Sahib, Haithem A. Al-Rubaie
doaj   +1 more source

نحو منهجية مزدوجة في تدريس القياس لأعمال البناء في التعليم المعماري الجامعي Towards A Dual Methodology in Teaching Measurement of Building Work In Undergraduate Architectural Education

Journal of Urban Research, 2021
يواجه التعليم الجامعي في مجال العمارة والبناء تحدياً کبيراً منذ ظهور تقنية نمذجة معلومات البناءBuilding information modelling (BIM) التي غيرت من أساليب الممارسة الفعلية لصناعة البناء، وطورت أيضا طرق وأساليب قياس الکميات وتقدير التکلفة لأعمال البناء، مما ...
Hanan Eissa
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Supporting Student Autonomy in Early School Education: Teaching Strategies, Challenges, and Conclusions from Pilot Studies

Forum Pedagogiczne
The aim of this article is to discuss the response strategies, actions, and styles of supporting student autonomy employed by early childhood education teachers.
Katarzyna Błażejewska
doaj   +1 more source

Innovative teaching methods applicable at the classes of percussion instruments

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2020
About 100 years have passed since the first classes of percussion instruments appeared. In the early days, when professional training intended for percussion performers dated to, teachers faced a large number of problems, in particular, lack of a full ...
Ralo Ganna
doaj   +1 more source

Using interactive teaching methods in the circle work [PDF]

, 2013
У статті аналізуються підходи вчених до формулювання поняття «інтерактивне навчання», подається власне його трактування, обґрунтовані методи інтерактивного навчання, які сприяють ефективному розвитку активності й комунікативності вихованців у ході занять
Budnik, Svitlana V., Буднік, Світлана Василівна   +1 more
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Using Progressive Pedagogies to Enhance Learner Autonomy [PDF]

, 2016
In this presentation I firstly review different approaches and methods that have been used to teaching English. Based on these approaches and methods, our understanding of how students learn their second language has been greatly enhanced.
Miller, L. (Lindsay)
core  

Emerging trends on the topic of Information Technology in the field of Educational Sciences: a bibliometric exploration [PDF]

, 2015
The paper presents a bibliometric analysis on the topic of Information Technology (IT) in the field of Educational Sciences, aimed at envisioning the research emerging trends.
González-Valiente, C. L.
core   +4 more sources