Results 131 to 140 of about 688,079 (278)

The macroscopic effects of microscopic heterogeneity

, 2012
Over the past decade, advances in super-resolution microscopy and particle-based modeling have driven an intense interest in investigating spatial heterogeneity at the level of single molecules in cells.
Aleksic, Andrews, Andrews, Aoki, Asakura, Bancaud, Banks, Berg, Betzig, Bray, Bray, Burack, Bénichou, Chevalier, Dard, Duke, Eggeling, Ellis, Ferrell, Ferrell, Gerland, Golding, Gopalakrishnan, Govern, Gowers, Grecco, Gurry, Hancock, Hattne, Hell, Howard, Hu, Huang, Kalay, Kholodenko, Kinkhabwala, Kolch, Koshland, Kusumi, Kusumi, Kusumi, Lagerholm, Li, Lingwood, Lis, Locasale, Lomholt, Lommerse, Lutkenhaus, Machta, Markevich, Mello, Miller, Monod, Morelli, Mugler, Murakoshi, Muramatsu, Nash, Oh, Pike, Plimpton, Plowman, Prior, Redner, Rust, Sauro, Simons, Sourjik, Sourjik, Stanford, Takahashi, Tian, Tkačik, Valitutti, van Albada, van Zon, van Zon, Wartlick, Weiss, Wofsy, Zhao, Zimmerman, Zimmerman   +83 more
core   +1 more source

PD-L1 autoregulation promotes the proliferation, migration and invasion of glioblastoma cells via GP130/JAK2/STAT3/IRAK2/IL6 signaling pathway

Scientific Reports
Glioblastoma (GBM) cells mediate immunosuppressive microenvironment, leading to poor response to programmed death-ligand 1(PD-L1) inhibitor therapy. How PD-L1 in GBM cells confers to GBM immunosuppressive microenvironment remains unclear.
Xin Xie, Jingdi Bai, Yuhui Peng, Pingping Chen, Zhuxue Zhang, Daogui Fan, Feng Zhou, Yuan Yuan, Jiyun Liu, Yu Zhou, Qin Hong, Jianjun Hu, Juanjuan Duan, Wenli Fu, Ting Zhang, Hongmei Zeng, Jie Deng, Yangting Dong, Ying Liu, Xiaolan Qi, Wei Hong, Yan He, Chunlin Zhang, Wenfeng Yu, Qintian Yang, Wei Yi, Hua Bai, Qifang Zhang   +27 more
doaj   +1 more source

IL-6; transcription factor activator protein -1 (AP-1); jun N-terminal kinase (JNK) [PDF]

, 2008

openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury [PDF]

, 2017
Svenja Sydor, Paul Manka, Jan Best, Sami Jafoui, Jan‐Peter Sowa, Miguel Eugenio Zoubek, Virginia Hernández–Gea, Francisco Javier Cubero, Julia Kälsch, Diana Vetter, Maria Isabel Fiel, Yujin Hoshida, C. Billie Bian, Leonard J. Nelson, Han Moshage, Klaas Nico Faber, Andreas Paul, Hideo A. Baba, Guido Gerken, Scott L. Friedman, Ali Canbay, Lars P. Bechmann   +21 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Genomic and proteomic profiling of responses to toxic metals in human lung cells. [PDF]

, 2003
Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response ...
Andrew, Angeline S, Barchowsky, Aaron, Hamilton, Joshua W, Klei, Linda, O'Hara, Kimberley A, Soucy, Nicole V, Temple, Kaili A, Warren, Amy J   +7 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cloning and expression of the FtWRKY28 gene from Fagopyrum tataricum under low phosphorus and hormone treatment

Xibei zhiwu xuebao
[Objective] WRKY transcription factors are involved in response to low phosphorus stress in plants. Based on transcriptome data of Tartary buckwheat (Fagopyrum tataricum ) under low phosphorus stress, the aim of this study is to isolate FtWRKY28 gene ...
WEN Biyao, PENG Xixu, TIAN Jianhong, WU Qingtao, WANG Haihua, TANG Xinke   +5 more
doaj   +1 more source