Results 111 to 120 of about 1,731,917 (295)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Study on the drying kinetics of Rosa flower buds using different drying methods

Research in Agricultural Engineering
This study investigated the drying kinetics of Rosa flower buds (Rosa damascene Mill) under environmental conditions (shade), as well as in direct and indirect solar dryers.
Hamid Reza Gazor, Omid Reza Roustapour
doaj   +1 more source

Role of Vanadium Addition on Hot Deformation Behavior of Aluminum Alloy 5083

Metals, 2019
The effect of V addition on the hot deformation behavior of AA5083 was investigated. Single axial compression tests were conducted on the cast and homogenized samples with strain rates ranging from 0.01 to 10 s−1 and deformation temperatures ...
Lijuan Wang, Xiangjie Wang, Xiao Zhu, Xin Xu, Jianzhong Cui, Bin Liao, Xiaodong Wang, Xiaodong Wu   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Rifampicin Nanopatricles: Thermodynamic Properties in KCl Electrolyte Using Cyclic Voltammetry

Nano Biomedicine and Engineering
Rifampicin nanoparticles (RF NPs) was sunthesized by lyophilization method and characterized by using scanning electron spectroscopy (SEM) and atomic force spectroscopy (AFM). It is found that the dimension of the RF NPs was 85.74 nm.
Sali Nabeel Jabrou, Muhammed Mizher Radhi, Emad Abbas Jaffar Al-Mulla, Ebaa Adnan Azooz   +3 more
doaj   +1 more source

Effect of Pyrolysis Temperature on the Electrical Property and Photosensitivity of a PAN-PMMA Derived Carbon Fiber

ChemEngineering, 2019
Fibers are promising materials being utilized in electronics, principally in the areas of capacitors and sensors. In this study, we examine the effect of pyrolysis temperature on the electrical conductive behavior and photosensitivity of a carbon-based ...
Tyler Xu, Antonino Nguyen, Noe Rosas, Isidro Flores, Cindy Chen, Jeremy B. Gan, Anan S. Hamdan, Yong X. Gan   +7 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Assessment of Insulation Aging Condition for Dry-Type Transformer Epoxy Resin Based on Dielectric Response and Activation Energy Analysis

Energies
The accurate assessment of the aging state of epoxy resin insulation is critical for the safe operation of cast resin dry-type transformers. This study investigates the evolution of activation energy during thermal aging and its correlation with ...
Yu Dong, Youhang Wang, Zhiqiang Li, Ning Lei, Yanchen Wei, Bin Song   +5 more
doaj   +1 more source

Hot forming of AISI A2 tool steel [PDF]

Metalurgija, 2008
For further increase of economy of production of AISI A2 tool steel a study of possibility of expanding the hot working range and better prediction of flow stress has been carried out.
T. Večko Pirtovšek, I. Peruš, G. Kugler, R. Turk, M. Terčelj   +4 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source