Results 141 to 150 of about 890,650 (312)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Activation energy and critical current density in Bi-Sr-Ca-Cu-O

, 1992
Flux creep in a Bi-Sr-Ca-Cu-0 system has been investigated in wide temperature and field regimes. Previously reported studies of the flux-creep activation energy U have been controversial in terms of the temperature and field dependence, and the U values
Shi, Donglu, Smith, M., Sengupta, S., Wang, Z.   +3 more
core   +1 more source

Demonstration of Gate-Related Trap Characterization in 4H-SiC MOSFETs Using Gate Stress Leakage Current

IEEE Journal of the Electron Devices Society
In this work, we demonstrate an innovative technique to characterize the gate-related traps in 4H-SiC MOSFETs by using the gate voltage stress-induced gate leakage current (GSLC) based on the Bayesian Deconvolution technique.
Shivendra Kumar Singh, Tian-Li Wu, Yogesh Singh Chauhan   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells

, 2011
Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex ...
Adrian J. L. Clark, Szidonya, L, Laszlo Szidonya, Cooray, SN, Mazhar, K, Teng-Teng Chung, Clark, AJ, Khansa Mazhar, Chung, TT, Sadani N. Cooray   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pyrolysis kinetic and product analysis of different microalgal biomass by distributed activation energy model and pyrolysis-gas chromatography-mass spectrometry

, 2014
To assess the energy potential of different microalgae, Chlorella sorokiniana and Monoraphidium were selected for studying the pyrolytic behavior at different heating rates with the analytical method of thermogravimetric analysis (TG), distributed ...
Sun, Yuan, Geng, Shu, Cheng, Jay Jiayang, Zhang, Rui, Fu, Juan, Yang, Xuewei   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impact of the carbonisation temperature on the activation of carbon fibres and their application for hydrogen storage

, 2008
Special issue: 2nd World Congress of Young Scientists on Hydrogen Energy Systems.Porous materials are gaining interest due to their potential for storing hydrogen via physisorption.
Suárez García, Fabián, Cazorla-Amorós, Diego, Weinberger, Benno, Kunowsky, Mirko, Linares-Solano, Angel, Lamari Darkrim, Farida   +5 more
core   +1 more source

Study on the crystallization kinetics of Ni-Mn-Sn-Fe alloy thin films

Materials Research Express
This study examines the crystallization kinetics of Ni _50−x Mn _39 Sn _11 Fe _x (x = 0, 0.5, 2, 4 at.%) amorphous thin films prepared by DC magnetron sputtering. SEM and XRD confirm their amorphous structure.
Shibin Li
doaj   +1 more source