Results 171 to 180 of about 17,207,076 (361)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

LiSA-MobileNetV2: an extremely lightweight deep learning model with Swish activation and attention mechanism for accurate rice disease classification

Frontiers in Plant Science
In the context of intelligent agriculture in China, rapid and accurate identification of crop diseases is essential for ensuring food security and improving crop yield.
Yongqi Xu, Dongcheng Li, Changcheng Li, Zheming Yuan, Zhijun Dai   +4 more
doaj   +1 more source

GAPCNN with HyPar: Global Average Pooling convolutional neural network with novel NNLU activation function and HYBRID parallelism. [PDF]

Front Comput Neurosci, 2022
Habib G, Qureshi S.
europepmc   +1 more source

Activation of AMPKα1 is essential for regulatory T cell function and autoimmune liver disease prevention

, 2021
Huaiping Zhu, Zhaoyu Liu, Junqing An, Miao Zhang, Yu Qiu, Ming‐Hui Zou   +5 more
openalex   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A novel activation function based recurrent neural networks and their applications on sentiment classification and dynamic problems solving. [PDF]

Front Neurorobot, 2022
Zhu Q, Tan M.
europepmc   +1 more source

Regulation of human neutrophil chemokine receptor expression and function by activation of Toll‐like receptors 2 and 4

, 2005
Ian Sabroe, Elizabeth C. Jones, Moira K. B. Whyte, Steven Dower   +3 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Position Control of a Pneumatic Drive Using a Fuzzy Controller with an Analytic Activation Function. [PDF]

Sensors (Basel), 2022
Šitum Ž, Ćorić D.
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source