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Alkyl derivative of p-terphenyl as an activator of the plastic scintillators with n/γ-discrimination ability [PDF]

Ядерна фізика та енергетика, 2023
In order to increase the solubility of p-terphenyl molecules, their structure was modified with tert-butyl groups. A derivative of p-terphenyl 2,4,4′-tris-tert-butyl-1,1′:4′,1′-terphenyl was obtained.
D. A. Yelisieiev, O. V. Yelisieieva, Yu. О. Нurkalenko, P. М. Zhmurin, V. D. Alekseev   +4 more
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Sirtuin Modulators in Cellular and Animal Models of Human Diseases

Frontiers in Pharmacology, 2021
Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through working on different substrate proteins, they display many biological functions, including regulation of cell proliferation, genome stability, metabolism, and cell ...
Jun Young Hong, Hening Lin, Hening Lin
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The Double-Edged Sword of SIRT3 in Cancer and Its Therapeutic Applications

Frontiers in Pharmacology, 2022
Reprogramming of cellular energy metabolism is considered an emerging feature of cancer. Mitochondrial metabolism plays a crucial role in cancer cell proliferation, survival, and metastasis.
Shumin Ouyang, Qiyi Zhang, Linlin Lou, Kai Zhu, Zeyu Li, Peiqing Liu, Xiaolei Zhang   +6 more
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Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

Frontiers in Pharmacology, 2021
Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding.
Yanan Liu, Yanan Liu, Canwei Wang, Jifa Li, Jiandong Zhu, Chengguang Zhao, Chengguang Zhao, Huanhai Xu   +7 more
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The Role and Therapeutic Perspectives of Sirtuin 3 in Cancer Metabolism Reprogramming, Metastasis, and Chemoresistance

Frontiers in Oncology, 2022
Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, acts as a metabolic modulator mainly located in mitochondria via regulating the process of the relevant biochemical processes by targeting crucial mediators. Recently,
QingYi Zhao, Jing Zhou, Feng Li, Sen Guo, Liang Zhang, Jing Li, Qin Qi, Qin Qi, Yin Shi, Yin Shi   +9 more
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Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies

Biomolecules, 2020
To study the structure and function of the pH-regulated receptor tyrosine kinase insulin receptor-related receptor (IRR), а member of the insulin receptor family, we obtained six mouse monoclonal antibodies against the recombinant IRR ectodomain.
Alexander S. Goryashchenko, Andrey A. Mozhaev, Oxana V. Serova, Tatiana N. Erokhina, Alexander N. Orsa, Igor E. Deyev, Alexander G. Petrenko   +6 more
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A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate

Molecules, 2022
SIRT1, an NAD+-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD+ into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr).
Nian-Da Yu, Bing Wang, Xin-Zhu Li, Hao-Zhen Han, Dongxiang Liu   +4 more
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Efficiency comparison of mixture formulations in the stabilisation/solidification of the loess silt contaminated with zinc in terms of mechanical properties

Budownictwo i Architektura, 2023
The effectiveness of various types of binders in stabilizing/solidifying (S/S) contaminated soils is strongly dependent on the type of soil and contaminants present.
Agnieszka Lal, Joanna Fronczyk, Małgorzata Franus   +2 more
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Lastik Karışımlarında Klasik ZnO Yerine Aktif ZnO Kullanımının Bazı Fizikomekanik Özelliklere Etkilerinin Araştırılması

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2022
Kauçuk esaslı ürünlerin imalatında kullanılan katkı malzemeleri; zamana, maruz kaldığı fiziksel ve kimyasal etkilere bağlı olarak üründen kısmen ayrılmaktadırlar.
Gasim Altundal, Tuğçe Görmüşer, İlyas Uygur, Hüsnü Gerengi, Metin Kuru, Esra Çetin   +5 more
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Preparation and Oxidation Resistance of Mo-Si-B Coating on Nb-Si Based Alloy Surface

Cailiao gongcheng, 2018
Mo-Si-B coating was prepared on Nb-Si alloys to improve the high-temperature oxidation. The influence of the halide activators (NaF and AlF3) on Si-B co-depositing to obtain Mo-Si-B coating on Nb-Si alloys was analyzed by thermochemical calculations. The
PANG Jie, ZHOU Chun-gen
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