Results 181 to 190 of about 338,751 (320)

Central Administration of Leptin Inhibits Food Intake and Activates the Sympathetic Nervous System in Rhesus Macaques¹ [PDF]

, 1999
Mads Tang‐Christensen, Peter J. Havel, Rebecca R. Jacobs, Philip J. Larsen, Judy L. Cameron   +4 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Anticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case Series. [PDF]

TH Open
Wang W, Gao Y, Qiao Y, Wu Y, Li J, Zhang L.   +5 more
europepmc   +1 more source

Nociceptive Stimuli Activate the Hypothalamus–Habenula Circuit to Inhibit the Mesolimbic Reward System and Cocaine-Seeking Behaviors

, 2022
Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen, Hee Young Kim   +7 more
openalex   +2 more sources

Turing patterns in network-organized activator-inhibitor systems

Turing patterns in network-organized activator-inhibitor systems
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Exploring the role of C1-inhibitor in thrombotic diseases. [PDF]

Blood Adv
Hansen JB.
europepmc   +1 more source

Evidence for activation of the tissue kallikrein‐kinin system in nociceptive transmission and inflammatory responses of mice using a specific enzyme inhibitor

, 2000
José Artur da Silva Emim, Caden Souccar, Maria S. de Abreu Castro, Rosely Oliveira Godinho, Maria Helena S. Cezari, L. Juliano, A.J. Lapa   +6 more
openalex   +2 more sources

Supplementary Table 7 from Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma

, 2023
Hao Liu, Kamila Naxerova, Matthias Pinter, João Incio, Hang Lee, Kohei Shigeta, William W. Ho, Jonathan A. Crain, Alex Jacobson, Theodoros Michelakos, Daniella Dias-Santos, Andrea Zanconato, Theodore S. Hong, Jeffrey W. Clark, Janet E. Murphy, David P. Ryan, Vikram Deshpande, Keith D. Lillemoe, Carlos Fernández‐del Castillo, Michael Downes, Ronald M. Evans, James Michaelson, Cristina R. Ferrone, Yves Boucher, Rakesh K. Jain   +24 more
openalex   +1 more source