Results 91 to 100 of about 3,963,692 (395)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
The genetic and dietary landscape of the muscle insulin signalling network
eLifeMetabolic disease is caused by a combination of genetic and environmental factors, yet few studies have examined how these factors influence signal transduction, a key mediator of metabolism. Using mass spectrometry-based phosphoproteomics, we quantified
Julian van Gerwen +9 more
doaj +1 more source
Frontiers in Endocrinology, 2017 Cardiovascular diseases (CVD) remain as the leading cause of mortality in the western world and have become a major health threat for developing countries. There are several risk factors that account for the CVD and the associated mortality.
Kwame Osei, Trudy Gaillard
doaj +1 more source
RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression [PDF]
, 2016 Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress.
Tsai, Michelle
core +1 more source
Epigenetic control of Epstein–Barr virus transcription – relevance to viral life cycle? [PDF]
, 2013 DNA methylation normally leads to silencing of gene expression but Epstein–Barr virus (EBV) provides an exception to the epigenetic paradigm. DNA methylation is absolutely required for the expression of many viral genes.
Sinclair, Alison J
core +2 more sources
A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation
PLoS Genetics, 2009 Hypermutation of the immunoglobulin (Ig) genes requires Activation Induced cytidine Deaminase (AID) and transcription, but it remains unclear why other transcribed genes of B cells do not mutate. We describe a reporter transgene crippled by hypermutation
A. Blagodatski +6 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
CRISPR/Cas9 Mediated Genome Engineering for Improvement of Horticultural Crops
Frontiers in Plant Science, 2017 Horticultural crops are an important part of agriculture for food as well as nutritional security. However, several pests and diseases along with adverse abiotic environmental factors pose a severe threat to these crops by affecting their quality and ...
Suhas G. Karkute +4 more
doaj +1 more source
Autism: genetics, environmental stressors, maternal immune activation, and the male bias in autism [PDF]
, 2022 Sarah Otaru, David A. Lawrence
openalex +1 more source
Genetic Determinants for Leisure-Time Physical Activity [PDF]
Medicine & Science in Sports & Exercise, 2018 ABSTRACT Purpose Leisure-time physical activity (LTPA) is a well-established modifiable lifestyle determinant for multiple cardiometabolic outcomes. However, current understanding of the genetic architecture that may determine LTPA remains very limited.
Xiaochen, Lin +8 more
openaire +2 more sources