Results 111 to 120 of about 3,963,692 (395)

Human genetics implicates a BACH2-NRF2 axis in fetal hemoglobin activation [PDF]

, 2023
Liam D. Cato, Rick Li, Henry Y. Lu, Fulong Yu, Mariel Wissman, Baraka Stewart Mkumbe, Supachai Ekwattanakit, Patrick Deelen, Liberata Mwita, Raphael Zozimus Sangeda, Thidarat Suksangpleng, Suchada Riolueang, Paola G. Bronson, Dirk S. Paul, Emily Kawabata, William J. Astle, François Aguet, Kristin Ardlie, Aitzkoa Lopez de Lapuente Portilla, Guolian Kang, Yingze Zhang, Mehdi Nouraie, Victor R. Gordeuk, Mark T. Gladwin, Melanie E. Garrett, Allison E. Ashley‐Koch, Marilyn J. Telen, Brian Custer, Shannon Kelly, Carla Luana Dinardo, Éster Cerdeira Sabino, Paula Loureiro, Anna Barbara F. Carneiro‐Proietti, Cláudia Máximo, Adriana Méndez, Angelika Hammerer‐Lercher, Vivien Sheehan, Mitchell J. Weiss, Lude Franke, Björn Nilsson, Adam S. Butterworth, Vip Viprakasit, Siana Nkya, Vijay G. Sankaran, Angelika Hammerer-Lercher, Julie Makani, Vivien A. Sheehan, Mitchell J. Weiss, Lude Franke, Björn Nilsson, Adam S. Butterworth, Vip Viprakasit, Siana Nkya, Vijay G. Sankaran   +53 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus

G3: Genes, Genomes, Genetics, 2017
Epilepsy has many causes and comorbidities affecting as many as 4% of people in their lifetime. Both idiopathic and symptomatic epilepsies are highly heritable, but genetic factors are difficult to characterize among humans due to complex disease ...
Russell J. Ferland, Jason Smith, Dominick Papandrea, Jessica Gracias, Leah Hains, Sridhar B. Kadiyala, Brittany O’Brien, Eun Yong Kang, Barbara S. Beyer, Bruce J. Herron   +9 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Personalized or Precision Medicine? The Example of Cystic Fibrosis

Frontiers in Pharmacology, 2017
The advent of the knowledge on human genetics, by the identification of disease-associated variants, culminated in the understanding of human variability. With the genetic knowledge, the specificity of the clinical phenotype and the drug response of each
Fernando A. L. Marson, Fernando A. L. Marson, Carmen S. Bertuzzo, José D. Ribeiro   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source