Results 111 to 120 of about 3,917,874 (426)

The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia.

Human Molecular Genetics, 1999
Acute promyelocytic leukaemia (APL) exhibits a characteristic t(15;17) translocation that fuses the promyelocytic leukaemia (PML) gene on 15q22 to the retinoic acid receptor alpha (RARA) gene on 17q12-q21.1.
C. Arnould, C. Philippe, V. Bourdon, M. Grégoire, R. Berger, P. Jonveaux   +5 more
semanticscholar   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Results of Evolution Supervised by Genetic Algorithms [PDF]

arXiv, 2010
A series of results of evolution supervised by genetic algorithms with interest to agricultural and horticultural fields are reviewed. New obtained original results from the use of genetic algorithms on structure-activity relationships are reported.
arxiv  

Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.

Human Molecular Genetics, 2004
NR2E3, a photoreceptor-specific orphan nuclear receptor, is believed to play a pivotal role in the differentiation of photoreceptors. Mutations in the human NR2E3 gene and its mouse ortholog are associated with enhanced S-cones and retinal degeneration ...
Hong Cheng, H. Khanna, Edwin C. T. Oh, D. Hicks, K. Mitton, A. Swaroop   +5 more
semanticscholar   +1 more source

Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila [PDF]

, 1995
The bithorax complex (BX-C) of Drosophila, one of two complexes that act as master regulators of the body plan of the fly, has now been entirely sequenced and comprises approximate to 315,000 bp, only 1.4% of which codes for protein.
Celniker, Susan E., Knafels, John D., Lewis, Edward B., Mathog, David R.   +3 more
core   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Disparities in Cardiovascular Disease and Type 2 Diabetes Risk Factors in Blacks and Whites: Dissecting Racial Paradox of Metabolic Syndrome

Frontiers in Endocrinology, 2017
Cardiovascular diseases (CVD) remain as the leading cause of mortality in the western world and have become a major health threat for developing countries. There are several risk factors that account for the CVD and the associated mortality.
Kwame Osei, Trudy Gaillard
doaj   +1 more source

A genetic algorithm for structure-activity relationships: software implementation [PDF]

arXiv, 2009
The design and the implementation of a genetic algorithm are described. The applicability domain is on structure-activity relationships expressed as multiple linear regressions and predictor variables are from families of structure-based molecular descriptors.
arxiv  

Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.

Human Molecular Genetics, 2008
Mutations in SRPX2 (Sushi-Repeat Protein, X-linked 2) cause rolandic epilepsy with speech impairment (RESDX syndrome) or with altered development of the speech cortex (bilateral perisylvian polymicrogyria). The physiological roles of SRPX2 remain unknown
Barbara Royer-Zemmour, Magali Ponsole-Lenfant, Hyam Gara, P. Roll, C. Lévêque, A. Massacrier, G. Ferracci, J. Cillario, A. Robaglia-Schlupp, R. Vincentelli, P. Cau, P. Szepetowski   +11 more
semanticscholar   +1 more source

Stochastic activation in a genetic switch model [PDF]

Physical Review E, 2018
We study a biological autoregulation process, involving a protein that enhances its own transcription, in a parameter region where bistability would be present in the absence of fluctuations. We calculate the rate of fluctuation-induced rare transitions between locally-stable states using a path integral formulation and Master and Chapman-Kolmogorov ...
Hertz, John, Tyrcha, Joanna, Correales, Alvaro   +2 more
openaire   +4 more sources