Results 121 to 130 of about 262,173 (350)

The genetical activity of heterochromatin [PDF]

Proceedings of the Royal Society of London. Series B - Biological Sciences, 1944
Heterochromatic supernumerary chromosomes in various plants differ from the chromosomes of the regular complement in not being essential to normal growth and survival. They cannot, however, be genetically inert for they have been shown to affect the fitness of plants carrying them.
openaire   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

An archived activation tagged population of Arabidopsis thalianato facilitate forward genetics approaches [PDF]

, 2009
Stephen J. Robinson, Lily Tang, Brent AG Mooney, Sheldon McKay, Wayne E. Clarke, Matthew G. Links, Steven R. Karcz, Sharon Regan, Yun-Yun Wu, Margaret Y. Gruber, De-Jun Cui, Min Yu, Isobel A. P. Parkin   +12 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: Potential and limitations

Frontiers in Plant Science, 2011
Chemical genetics is a powerful scientific strategy that utilizes small bioactive molecules as experimental tools to unravel biological processes. Bioactive compounds occurring in nature represent an enormous diversity of structures that can be used to ...
Stéphanie eCottier, Timon eMönig, Zheming eWang, Jiří eSvoboda, Wilhelm eBoland, Markus eKaiser, Erich eKombrink   +6 more
doaj   +1 more source

A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in Macrophages [PDF]

, 2019
Yoon‐Suk Kang, James E. Kirby
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HISTONES OF GENETICALLY ACTIVE AND INACTIVE CHROMATIN [PDF]

The Journal of Cell Biology, 1967
It has frequently been proposed that a variation in the relative content of lysine-rich, moderately lysine-rich, and arginine-rich histones might provide a mechanism by which specific portions of the genome may be genetically regulated. This possibility was investigated by comparing the electrophoretic pattern of these three fractions in cells ...
openaire   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Epigenetic mechanisms, T-cell activation, andCCR5genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor [PDF]

, 2015
Germán G. Gornalusse, Srinivas Mummidi, Alvaro A. Gaitan, Fabio Jimenez, Veron Ramsuran, Anabela C.P. Picton, Kristen C Rogers, Muthu Saravanan Manoharan, Nymisha Avadhanam, Krishna K. Murthy, Hernan Martinez, Angela Molano Murillo, Z. A. Chykarenko, Richard Hutt, Demetre C Daskalakis, Ludmila Shostakovich-Koretskaya, Salim S. Abdool Karim, Jeffrey N. Martin, Steven G. Deeks, Frederick Hecht, Elizabeth Sinclair, Robert A. Clark, Jason F. Okulicz, Fred Valentine, Neil Martinson, Caroline T. Tiemessen, Thumbi Ndung’u, Peter W. Hunt, Weijing He, Sunil K. Ahuja   +29 more
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Engaging students in population genetics online: Genetic wheel activity

Biochemistry and Molecular Biology Education, 2023
Lara Grollo, Daniel Andrews, Lauren Salo
openaire   +2 more sources