Results 131 to 140 of about 3,917,874 (426)

Effect of promoter architecture on the cell-to-cell variability in gene expression [PDF]

, 2010
According to recent experimental evidence, the architecture of a promoter, defined as the number, strength and regulatory role of the operators that control the promoter, plays a major role in determining the level of cell-to-cell variability in gene ...
A Bar-Even, A Gansen, A Raj, A Raj, A Sanchez, A Singh, A Warmflash, AC Babic, AD Cameron, Alvaro Sanchez, B Muller-Hill, BS Burz, C Zurla, CD Cox, CD Cox, D Kennell, D Müller, D Nevozhay, D Zenklusen, Daniel Jones, DF Browning, DR Rigney, DT Gillespie, DW Austin, E Segal, EM Ozbudak, F Vanzi, F Vanzi, FMV Rossi, G Li, G Tkacik, H Boeger, H Maamar, HD Kim, HD Kim, Hernan G. Garcia, I Golding, IB Dodd, J Elf, J Gertz, J Müller, J Ou, J Paulsson, J Paulsson, J Peccoud, J Yu, Jané Kondev, JK Joung, JK Joung, JM Pedraza, JM Pedraza, JM Raser, JM Vilar, JM Vilar, JR Chubb, JS van Zon, K Gaston, KF Murphy, KS Koblan, L Bintu, L Bintu, L Cai, L Saiz, LS Weinberger, M Ackerman, M Dobrzynski, M Kaern, M Ptashne, M Shin, M Thattai, M Voliotis, MA Shea, MB Elowitz, MF Wernet, MJ Dunlop, N Maheshri, N Rosenfeld, NE Buchler, O Berg, OK Wong, PJ Choi, PJ Ingram, PJ Schlax, PS Gutierrez, PS Swain, R Losik, Rob Phillips, S Klumpp, S Semsey, SB Straney, SE Halford, T Höfer, T Kuhlman, T Raveh-Sadka, TB Kepler, TL To, TP Malan, TS Karpova, U Moran, V Shahrezaei, WJ Blake, WJ Blake, Wyeth W. Wasserman, Y Taniguchi, Y Wang   +104 more
core   +5 more sources

Genetic contribution to microglial activation in schizophrenia

Molecular Psychiatry
AbstractSeveral lines of evidence indicate the involvement of neuroinflammatory processes in the pathophysiology of schizophrenia (SCZ). Microglia are brain resident immune cells responding toward invading pathogens and injury-related products, and additionally, have a critical role in improving neurogenesis and synaptic functions.
Marja Koskuvi, Elina Pörsti, Tristen Hewitt, Noora Räsänen, Ying-Chieh Wu, Kalevi Trontti, Amanda McQuade, Shringaa Kalyanaraman, Ilkka Ojansuu, Olli Vaurio, Tyrone D. Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta, Markku Lähteenvuo, Taisia Rolova, Šárka Lehtonen, Jari Tiihonen, Jari Koistinaho   +21 more
openaire   +5 more sources

Genetic Variation in Selenoenzymes and Their Activity

The FASEB Journal, 2010
Selenium may protect against various diseases through the activity of selenoenzymes. However, little is known of the effect of genetic variation in selenoenzymes on their activity. We tested 37 tagging single nucleotide polymorphisms (SNPs) in the selenoenzyme genes, glutathione peroxidase1–4 (GPX1–4), selenoprotein P (SEPP1), and 15 kDa selenoprotein (
Raymond F. Burk, David Duggan, Patricia L. Blount, Johanna W. Lampe, Irena B. King, Thomas L. Vaughan, Yumie Takata, Alan R. Kristal, Kristina E. Hill, Brian J. Reid, Regina M. Santella, Ulrike Peters   +11 more
openaire   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Personalized or Precision Medicine? The Example of Cystic Fibrosis

Frontiers in Pharmacology, 2017
The advent of the knowledge on human genetics, by the identification of disease-associated variants, culminated in the understanding of human variability. With the genetic knowledge, the specificity of the clinical phenotype and the drug response of each
Fernando A. L. Marson, Fernando A. L. Marson, Carmen S. Bertuzzo, José D. Ribeiro   +3 more
doaj   +1 more source

Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex [PDF]

, 2012
A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the routing of information among prefrontal neuronal subtypes is the inability to manipulate the electrical activity of genetically defined ...
arxiv   +1 more source

The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]

, 2007
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton, al-Khodairy, Allshire, Allshire, Andrews, Apionishev, Branzei, Chakrabarti, Cheng, E.A. Outwin, Ekwall, F.-X. Ogi, F.Z. Watts, Grishchuk, Ho, Ho, Hoege, Hooker, J.C.-Y. Ho, Johnson, Kagey, Kahyo, L. Gardner, L.K. Boyd, M.A.M. Trickey, McDonald, Okubo, Pichler, Potts, Reindle, Sachdev, Schmidt, Sergeant, Shayeghi, Shin, Stelter, Strahl-Bolsinger, Tanaka, Taylor, Thon, Watts, Xhemalce, Xhemalce, Zhao, Zhao   +44 more
core   +2 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Design of artificial genetic regulatory networks with multiple delayed adaptive responses [PDF]

, 2016
Genetic regulatory networks with adaptive responses are widely studied in biology. Usually, models consisting only of a few nodes have been considered. They present one input receptor for activation and one output node where the adaptive response is computed.
arxiv   +1 more source

A model for selection of eyespots on butterfly wings [PDF]

, 2015
The development of eyespots on the wing surface of butterflies of the family Nympalidae is one of the most studied examples of biological pattern formation.However, little is known about the mechanism that determines the number and precise locations of ...
A Gierer, Anotida Madzvamuse, Chandrasekhar Venkataraman, CR Brunetti, DL Benson, H Meinhardt, H Meinhardt, HF Nijhout, HF Nijhout, HF Nijhout, J Raspopovic, J Schnakenberg, JD Murray, JL Aragon, JM Otaki, Jordi Garcia-Ojalvo, K Page, KL Prudic, M Stevens, O Lakkis, P Beldade, PM Brakefield, R Dillon, R Dilão, R Sheth, RA Barrio, RD Reed, SB Carroll, SB Carroll, T Sekimura, TM Evans, Toshio Sekimura, Y Shirota   +32 more
core   +4 more sources