Results 181 to 190 of about 4,610,135 (394)

A liver-heart endocrine axis revealed by systems genetics and mediated by hepatocyte growth factor activator [PDF]

Michał Juda, Dylan Sarver, Jenny Cheng, James R. Hilser, Xinmin S. Li, Tomohiro Yokota, Christopher Li, Calvin Pan, Zhibin Zhou, Adrian Arrieta, Marcus Seldin, Xia Yang, WH Wilson Tang, Thomas M. Vondriska, Stanley L. Hazen, Hooman Allayee, Aldons J. Lusis   +16 more
openalex   +1 more source

Genetics reveals importance of platelet activating factor in asthma and possibly other inflammatory states. [PDF]

, 1996
Jay A. Nadel
openalex   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The genetics of schizophrenia : the contribution of common variants and genes implicated in a maternal immune activation model

, 2016
Shing-wan Choi
openalex   +1 more source

C82 CARDIOMYOPATHIES AND GENETICS: ACTIVATION OF A SHARED PATH. INSIGHTS FROM CUNEO HOSPITAL [PDF]

, 2023
L Coppini, G Coletta, Roberta Rossini
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Molecular genetics of development studied in the transgenic mouse. [PDF]

, 1989
Gruss, P., Westphal, H.
core   +2 more sources

Medical genetics: advances in brief: An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia [PDF]

, 1998
D. O Robinson
openalex   +1 more source