Results 191 to 200 of about 4,610,135 (394)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise

, 2012
Brendon J. Gurd, Cameron Williams
openalex   +4 more sources

Bacteriophage T4 Genome

Microbiology and Molecular Biology Reviews, 2003
E. S. Miller, E. Kutter, G. Mosig, F. Arisaka, T. Kunisawa, W. Rüger   +5 more
semanticscholar   +1 more source

Glycoprotein-180 deficiency: genetics and abnormal neutrophil activation [PDF]

, 1985
SJ Weisman, RL Berkow, G Plautz, M Torres, WA McGuire, Thomas D. Coates, R A Haak, A Floyd, R Jersild, RL Baehner   +9 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

MB-28 * GENOME-WIDE COPY NUMBER ANALYSIS, NEUROPATHOLOGICAL CLASSIFICATION AND ANALYSIS OF HEDGEHOG ACTIVATION: HISTOLOGY REFLECTS GENETICS AND BIOLOGY IN MEDULLOBLASTOMAS OF YOUNG CHILDREN [PDF]

, 2015
E. Kapitza, Dorota Denkhaus, Anja zur Mühlen, Stefan Rutkowski, Torsten Pietsch   +4 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Author Correction: Disentangling the architectural and non-architectural functions of CTCF and cohesin in gene regulation. [PDF]

Nat Genet
Narita T, Kilic S, Higashijima Y, Scherer NM, Pappas G, Maskey E, Choudhary C.   +6 more
europepmc   +1 more source

Interstitial stem cells in Hydra [PDF]

, 1987
Bosch, Thomas C. G., David, Charles N., Hobmayer, Engelbert, Holstein, Thomas W., Loomis, W. F., Schmidt, Tobias   +5 more
core  

Optimized Gal4 genetics for permanent gene expression mapping in zebrafish

Proceedings of the National Academy of Sciences of the United States of America, 2009
M. Distel, M. Wullimann, R. Köster
semanticscholar   +1 more source