Results 271 to 280 of about 3,963,692 (395)

Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus.

Human Molecular Genetics, 2001
S. Wayne, N. G. Robertson, F. Declau, Nancy Chen, K. Verhoeven, Sai D. Prasad, Lisbeth Tranebjärg, C. Morton, Allen F. Ryan, G. Camp, R. H. Smith   +10 more
semanticscholar   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

FleQ-Dependent regulation of the ribonucleotide reductase repressor NrdR in Pseudomonas aeruginosa during biofilm growth and infection. [PDF]

Sci Rep
Marchan D, Rubio A, Pedraz L, Hernández JM, Admella J, Blanco-Cabra N, Torrents E.   +6 more
europepmc   +1 more source

The Genetics of Insulin Resistance: Analysis of the Peroxisome Proliferator-Activated Receptor Pathway [PDF]

, 2005
M. Y. Boudreaux
openalex  

Repair of Global Regulators in Staphylococcus aureus 8325 and Comparative Analysis with Other Clinical Isolates

Infection and Immunity, 2010
S. Herbert, A. Ziebandt, K. Ohlsen, T. Schäfer, M. Hecker, D. Albrecht, R. Novick, F. Götz   +7 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Serum miR-34a as Indicator of Impaired Fibrinolytic Capacity in Pediatric Thrombosis Through Inadequate Regulation of the ACE/PAI-1 Axis. [PDF]

Int J Mol Sci
Gintoni I, Baldouni K, Dettoraki A, Michalopoulou A, Papathanasiou I, Tsezou A, Vlachakis D, Pergantou H, Chrousos GP, Yapijakis C.   +9 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Coping Styles and Defense Mechanisms in Healthy Young Adults-Correlations with tPA-BDNF Pathway. [PDF]

Brain Sci
Pilecka J, Wojciechowski J, Bargiel W, Terczynska M, Zakowicz P, Bojarski D, Wasicka-Przewozna K, Skibinska M.   +7 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source