Results 61 to 70 of about 262,173 (350)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Genetically encodable biosensors for Ras activity [PDF]
RSC Chemical BiologyGenetically encoded Ras biosensors have illuminated the spatiotemporal dynamics of Ras activity since the start of the imaging revolution of the early 21st century, helping elucidate Ras signalling at various subcellular compartments.
Ryan Weeks, Sohum Mehta, Jin Zhang
openaire +3 more sources
Identification of a novel regulatory mechanism for the disease associated protein, uPAR [PDF]
, 2014 Expression quantitative trait loci (eQTLs), as determined through a series of statistical association studies collectively known as genome-wide association (GWA) studies, have provided us with a hypothesis free approach for the investigation into ...
Hall, Ian P. +2 more
core
Hidden long evolutionary memory in a model biochemical network
, 2017 We introduce a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. Starting with a functional core
Ali, Md. Zulfikar +2 more
core +1 more source
Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia [PDF]
, 2014 © The Author 2014. Published by Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution,
Al-Mahdawi +57 more
core +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Advanced Biomedical Research, 2014 Common variable immunodeficfiiency (CVID) is a primary immunodeficiency syndrome representing a heterogeneous set of disorders resulting mostly in antibody deficiency and recurrent infections. However, inflammatory and autoimmune disorders and some kinds
Reza Yazdani +4 more
doaj +1 more source
Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. [PDF]
PLoS Pathogens, 2008 In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient laboratory studies have identified mosquito genes that affect positively or negatively the ...
Antonio M Mendes +9 more
doaj +1 more source
Hematology, Transfusion and Cell Therapy, 2023 The myelodysplastic syndromes (MDS) are clonal bone marrow (BM) stem cell disease(s), characterized by abnormal hematopoiesis, with anemia (95%) and/or other cytopenias. The pathogenesis is based on genetics and inflammation of aging (inflammaging).
Moshe Mittelman
doaj +1 more source
An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]
, 2007 Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G. +7 more
core +2 more sources