Results 71 to 80 of about 3,917,874 (426)

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex [PDF]

, 2014
Peer reviewedPublisher ...
Alvino, Gina M., Brewer, Bonita J., Chang, FuJung, Donaldson, Anne D., Hiraga, Shinichiro, Kubota, Takashi, Lian, Huiyong, Raghuraman, M. K., Sridhar, Akila, Weinreich, Michael   +9 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Genetic defects and the role of helper T-cells in the pathogenesis of common variable immunodeficiency

Advanced Biomedical Research, 2014
Common variable immunodeficfiiency (CVID) is a primary immunodeficiency syndrome representing a heterogeneous set of disorders resulting mostly in antibody deficiency and recurrent infections. However, inflammatory and autoimmune disorders and some kinds
Reza Yazdani, Mazdak Ganjalikhani Hakemi, Roya Sherkat, Vida Homayouni, Rahim Farahani   +4 more
doaj   +1 more source

Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development

PLoS Genetics, 2011
Alternative splicing amplifies the information content of the genome, creating multiple mRNA isoforms from single genes. The evolutionarily conserved splicing activator Tra2β (Sfrs10) is essential for mouse embryogenesis and implicated in spermatogenesis.
S. Grellscheid, Caroline Dalgliesh, M. Storbeck, Andrew Best, Yilei Liu, M. Jakubik, Y. Mende, Ingrid Ehrmann, Tomaž Curk, Kristina Rossbach, Cyril F. Bourgeois, J. Stévenin, D. Grellscheid, M. Jackson, B. Wirth, D. Elliott   +15 more
semanticscholar   +1 more source

Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion [PDF]

, 2011
We investigated polymorphisms of plasminogen activator inhibitor-1 (PAI-1), angiotensin converting enzyme (ACE ) and coagulation factor XIII (FXIII) genes and their association with recurrent spontaneous abortion (RSA) in Iranian patients and normal ...
Aarabi, M., Aarabi, M., Akhondi, M.A., Arefi, S., Memariani, T., Modarressi, M.H., Zadeh, S.H.   +6 more
core  

The C-terminal extension of the beta 7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturation [PDF]

, 2007
The eukaryotic 20 S proteasome is formed by dimerization of two precursor complexes containing the maturation factor Ump1. beta 7/Pre4 is the only one of the 14 subunits forming the 20 S proteasome that is absent from these precursor complexes in ...
Dohmen, Juergen, Glanemann, Christoph, Marques, Antonio J., Ramos, Paula C.   +3 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Screening of Genes Related to Growth, Development and Meat Quality of Sahan Crossbred F1 Sheep Based on RNA-Seq Technology

Frontiers in Veterinary Science, 2022
This study aimed to identify genes related to sheep growth, development and meat quality. Small-tailed Han sheep (STH), and small-tailed Han sheep and Suffolk crossbred F1 (STH×SFK), were selected to determine the growth performance, slaughter ...
Yali Song, Quanwei Zhang, Jinping Shi, Lingjuan Fu, Shuru Cheng   +4 more
doaj   +1 more source

Information capacity of genetic regulatory elements [PDF]

Phys. Rev. E 78, 011910 (2008), 2007
Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need to perform non-trivial computations that integrate several inputs and affect multiple genes.
arxiv   +1 more source

Bio-logic: gene expression and the laws of combinatorial logic [PDF]

, 2008
Original article can be found at: http://www.mitpressjournals.org/ Copyright MIT Press DOI: 10.1162/artl.2008.14.1.121At the heart of the development of fertilized eggs into fully formed organisms and the adaptation of cells to changed conditions are ...
Arnone M. I., Chrystopher L. Nehaniv, Maria J. Schilstra, Yuh C.-H.   +3 more
core   +1 more source