Results 81 to 90 of about 3,917,874 (426)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. [PDF]

PLoS Pathogens, 2008
In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient laboratory studies have identified mosquito genes that affect positively or negatively the ...
Antonio M Mendes, Timm Schlegelmilch, Anna Cohuet, Parfait Awono-Ambene, Maria De Iorio, Didier Fontenille, Isabelle Morlais, George K Christophides, Fotis C Kafatos, Dina Vlachou   +9 more
doaj   +1 more source

Deep neural networks with controlled variable selection for the identification of putative causal genetic variants [PDF]

arXiv, 2021
Deep neural networks (DNN) have been used successfully in many scientific problems for their high prediction accuracy, but their application to genetic studies remains challenging due to their poor interpretability. In this paper, we consider the problem of scalable, robust variable selection in DNN for the identification of putative causal genetic ...
arxiv  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma

iScience, 2018
Summary: TUC338 is an ultraconserved long non-coding RNA that contributes to transformed cell growth in hepatocellular carcinoma (HCC). Genomic regions of TUC338 occupancy were enriched in unique or known binding motifs homologous to the tumor ...
Hui-Ju Wen, Michael P. Walsh, Irene K. Yan, Kenji Takahashi, Alan Fields, Tushar Patel   +5 more
doaj  

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analysesResearch in context

EBioMedicine, 2023
Summary: Background: Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets.
Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao Zhang, Han Zhang, Jianhui Zhao, Jie Zheng, Susanna C. Larsson, Xiaoyan Wang, Xue Li, Shuai Yuan   +11 more
doaj  

Genetically encodable biosensors for Ras activity [PDF]

RSC Chemical Biology
Genetically encoded Ras biosensors have illuminated the spatiotemporal dynamics of Ras activity since the start of the imaging revolution of the early 21st century, helping elucidate Ras signalling at various subcellular compartments.
Ryan Weeks, Sohum Mehta, Jin Zhang
openaire   +3 more sources

Genetic analysis of integrin activation in T lymphocytes [PDF]

Immunological Reviews, 2002
Summary: Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor.
Kellermann, Sirid-Aimée, Dell, Cheryl L., Hunt, Stephen W., Shimizu, Yoji   +3 more
openaire   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2

Microorganisms
The identification of four potential nonstructural 5 (NS5) residues—K28, K45, V335, and S749—that share the same amino acid preference in STAT2-interacting flaviviruses [Dengue virus (DENV) and Zika virus (ZIKV)], but not in STAT2-non-interacting ...
Nias Y. G. Peng, Julian D. J. Sng, Yin Xiang Setoh, Alexander A. Khromykh   +3 more
doaj   +1 more source