Results 81 to 90 of about 3,963,692 (395)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Metabolomic architecture of obesity implicates metabolonic lactone sulfate in cardiometabolic disease

Molecular Metabolism, 2021
Objective: Identify and characterize circulating metabolite profiles associated with adiposity to inform precision medicine. Methods: Untargeted plasma metabolomic profiles in the Insulin Resistance Atherosclerosis Family Study (IRASFS) Mexican American ...
Swapan K. Das, Hannah C. Ainsworth, Latchezar Dimitrov, Hayrettin Okut, Mary E. Comeau, Neeraj Sharma, Maggie C.Y. Ng, Jill M. Norris, Yii-der I. Chen, Lynne E. Wagenknecht, Donald W. Bowden, Fang-Chi Hsu, Kent D. Taylor, Carl D. Langefeld, Nicholette D. Palmer   +14 more
doaj   +1 more source

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4 [PDF]

, 2017
Background: The transcription factor interferon regulatory factor 4 (IRF4) was identified to be involved in human pigmentation by genome-wide association studies (GWASs).
Cai, Xinzhang, Chen, Hongsheng, Feng, Yong, He, Chufeng, Li, Jiada, Liu, Huadie, Liu, Xueming, Liu, Yalan, Mei, Lingyun, Peng, Zhen, Song, Jian, Vleminckx, Kris   +11 more
core   +1 more source

Genetic Defects of Phagocyte Nadph Oxidase Activity and Activation

International Journal of Immunopathology and Pharmacology, 1989
NADPH oxidase is the key enzyme of the free radical-generating oxidative matabolism of phagocytes. Work from our and other's laboratories has recently established that the oxidase is not a single molecular entity, but it is a multicomponent system including a NADPH-binding protein, a flavoprotein, a b-type cytochrome and other unidentified factors.
BELLAVITE, Paolo, BAZZONI, Flavia, SCOLARO G, POLI G, DUSI, Stefano, CASSATELLA, Marco Antonio   +5 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Residue K28 of Zika Virus NS5 Protein Is Implicated in Virus Replication and Antagonism of STAT2

Microorganisms
The identification of four potential nonstructural 5 (NS5) residues—K28, K45, V335, and S749—that share the same amino acid preference in STAT2-interacting flaviviruses [Dengue virus (DENV) and Zika virus (ZIKV)], but not in STAT2-non-interacting ...
Nias Y. G. Peng, Julian D. J. Sng, Yin Xiang Setoh, Alexander A. Khromykh   +3 more
doaj   +1 more source

Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. [PDF]

PLoS Pathogens, 2008
In much of sub-Saharan Africa, the mosquito Anopheles gambiae is the main vector of the major human malaria parasite, Plasmodium falciparum. Convenient laboratory studies have identified mosquito genes that affect positively or negatively the ...
Antonio M Mendes, Timm Schlegelmilch, Anna Cohuet, Parfait Awono-Ambene, Maria De Iorio, Didier Fontenille, Isabelle Morlais, George K Christophides, Fotis C Kafatos, Dina Vlachou   +9 more
doaj   +1 more source

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]

, 2004
Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould, Bhunia, Duyndam, Giles, Grotewold, Huan, Kim, Kimberling, Kugoh, Loghman-Adham, Löhning, Morin, Moser, Muto, Newby, Ouwens, Parnell, Peters, Pritchard, Rivat, Rodova, Saadi-Kheddouci, Scheffers, Shaulian, Smits, Sorenson, Spaargaren, Streets, Sutters, Trudel, Upadhya, van Adelsberg, van Dam, van Dam, van Dam, van Dam, van de Wetering, van de Wetering   +37 more
core   +3 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Hidden long evolutionary memory in a model biochemical network

, 2017
We introduce a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. Starting with a functional core
Ali, Md. Zulfikar, Mukhopadhyay, Ranjan, Wingreen, Ned S.   +2 more
core   +1 more source