Results 121 to 130 of about 13,165,078 (297)

Editorial: The Present and Future of Immunology Education

open access: yesFrontiers in Immunology, 2021
Andrea Bottaro   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

RESEARCH ON THE LABOUR FORCE FROM ROMANIAN AGRICULTURE [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2014
Through this research is analyzed labor force from Romanian agriculture. The agriculture in Romania has a very large share in the Gross Domestic Product (GDP).
Nicoleta MATEOC-SÎRB   +3 more
doaj  

Active Galactic Nuclei

open access: yes, 2010
This work represents the final year project for BSc Physics with Astrophysics degree and it mainly focuses on empirical investigation of the photometry of quasars in the Sloan Digital Sky Survey (SDSS) and the UK Infrared Telescope (UKIRT) Infrared Sky ...
Khassen, Yerbol Farkhatuly
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

KONTRASTIVE ANALYSE DES PASSIVS IM DEUTSCHEN UND SLOWAKISCHEN

open access: yesLinguarum Universe
The use of abbreviations in all layers of the specific socio-political vocabulary and in press language is becoming a characteristic of German. For more than 60 years, abbreviations have experienced a veritable "boom" in the German language, often ...
Viera LAGEROVÁ, Alica HARAJOVÁ
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Study to Delineate the Immunohistological Parameters of Active Versus Stable Vitiligo Using S100, Melan A in Conjunction with CD4 and CD8 Immunohistochemistry Markers

open access: yesIndian Dermatology Online Journal
Background: Vitiligo is an autoimmune pigmentary disorder where it is important to assess the disease status (active/stable) to guide therapeutic decisions.
Sai Jyoti   +4 more
doaj   +1 more source

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