Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Dialectic Form Finding of Passive and Adaptive Shading Enclosures
Energies, 2014 Form finding describes the process of finding a stable equilibrium shape for a system under a specific set of loads, for a set of boundary conditions and starting from an arbitrary initial geometry.
Sigrid Adriaenssens +6 more
doaj +1 more source
Five ways to model active processes in elastic solids: Active forces, active stresses, active strains, active fibers, and active metrics [PDF]
Mechanics Research Communications, 2018 An important contribution of Gerard Maugin was his study of anelasticity. It is well appreciated that in biological systems, anelasticity manifests itself through growth and remodeling and Maugin and his collaborators have helped build a general theory suitable to model such fundamental processes.
openaire +1 more source
Clinical Effects of a Topically Applied Toll-like Receptor 9 Agonist in Active Moderate-to-Severe Ulcerative Colitis [PDF]
, 2016 Raja Atreya +16 more
openalex +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Biomechanical analysis of different lifting speeds when using an active exoskeleton
Frontiers in Bioengineering and BiotechnologyIntroductionMusculoskeletal disorders (MSDs), especially lower back pain, are common consequences of repetitive and long-term mechanical stress. Exoskeletons offer a promising approach to reduce this stress by supporting the wearer during physical labour.
Dominik Mayer +5 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Active, Passive, and Absorptive RIS-Aided 6G Network Under Non-Orthogonal CCI
IEEE Open Journal of Vehicular TechnologyThis paper investigates the impact of randomly deployed non-orthogonal co-channel interference (CCI), originating from the information exchange process among non-orthogonal multiple access (NOMA) users, in an active, passive, and absorptive ...
Volkan Ozduran +4 more
doaj +1 more source