Results 51 to 60 of about 3,307,588 (255)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Should we care for structural breaks when assessing fiscal sustainability? [PDF]

We apply recent panel cointegration methods to a structural equation between government expenditure and revenue. Allowing for multiple endogenous breaks and after computing appropriate bootstrap critical values, we conclude for fiscal sustainability in ...
António Afonso, Christophe Rault
core   +4 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Detrending procedures and cointegration testing: ECM tests under structural breaks [PDF]

, 1998
It is well known that all the test for unit roots and cointegration depend on the deterministic elements that are in mean of the variables; constant, trend, breaks, outliers, segmented trends, etc. This is a serious inconvenient for empirical work.
Escribano, Álvaro, Arranz, Miguel A.
core   +1 more source

The effect of booster breaks on non-specific low back pain in office workers

Annales Kinesiologiae
Purpose: Prolonged sitting has a negative effect on office workers, and non-specific low back pain (NSLBP) is one of the most common consequences of an inactive lifestyle and prolonged sitting.
Tajda Uršič, Uroš Marušič
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

THE “IMOLA ACTIVE BREAKS STUDY”: IMPLEMENTATION OF CLASSROOM PHYSICAL ACTIVITY BREAKS INTERVENTIONS

, 2020
Book of Abstracts of the 25th Annual Congress of the European College of Sport Science – 28th - 30th October ...
MASINI ALICE, MARINI SOFIA, BARONE GIUSEPPE, BRAGONZONI LAURA, BISI MARIA CRISTINA, CECILIANI ANDREA, CAMPA FRANCESCO, GRIGOLETTO ALESSIA, GORI DAVIDE, TESSARI ALESSIA, TOSELLI STEFANIA, STAGNI RITA, DALLOLIO LAURA.   +12 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]

, 2012
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua, Rajendran, Anbazhagan, Jagesh V. Shah (116400), Anyong Xie (116396), Gunnar Schotta (116394), Anbazhagan Rajendran (116388), Yinghua Guan (116385), Anyong Xie, Yinghua Guan, Ralph Scully, Hartlerode, Andrea J., Andrea J Hartlerode, Anbazhagan Rajendran, Gunnar Schotta, Andrea J. Hartlerode, Jagesh V. Shah, Jagesh V Shah, Andrea J. Hartlerode (116383), Ralph Scully (116402), Xie, Anyong, Shah, Jagesh, Ura, Kiyoe, Kiyoe Ura (116391), Scully, Ralph, Kiyoe Ura, Schotta, Gunnar, Shah, Jagesh V.   +26 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source