Results 51 to 60 of about 213,549 (261)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Environmental leapfrogging: Paths and strategies to decarbonise transport in Ethiopia

Transportation Research Interdisciplinary Perspectives
Carbon dioxide emissions from passenger transportation are increasing worldwide and especially in developing countries (DCs). Maintaining a conventional approach to transportation, which is resource-intensive and environmentally damaging, and pursuing ...
Mulugeta Getu Sisay
doaj   +1 more source

Surface and interface chemistry in metal‐free electrocatalysts for electrochemical CO2 reduction

SmartMat, 2022
The electrochemical reduction of carbon dioxide (CO2) into value‐added fuels and chemicals presents a sustainable route to alleviate CO2 emissions, promote carbon‐neutral cycles and reduce the dependence on fossil fuels.
Wei Zhang, Baohua Jia, Xue Liu, Tianyi Ma   +3 more
doaj   +1 more source

Simulation-Based and Data-Driven Techniques for Quantifying the Influence of the Carbon Binder Domain on Electrochemical Properties of Li-Ion Batteries

Energies, 2022
Most cathode materials for Li-ion batteries exhibit a low electronic conductivity. Therefore, a considerable amount of conductive additives is added during electrode production.
Tobias Knorr, Simon Hein, Benedikt Prifling, Matthias Neumann, Timo Danner, Volker Schmidt, Arnulf Latz   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Machine-learning-assisted material discovery of oxygen-rich highly porous carbon active materials for aqueous supercapacitors

Nature Communications, 2023
Porous carbons are the active materials of choice for supercapacitor applications because of their power capability, long-term cycle stability, and wide operating temperatures.
Tao Wang, Runtong Pan, Murillo L. Martins, Jinlei Cui, Zhennan Huang, Bishnu P. Thapaliya, Chi-Linh Do-Thanh, Musen Zhou, Juntian Fan, Zhenzhen Yang, Miaofang Chi, Takeshi Kobayashi, Jianzhong Wu, Eugene Mamontov, Sheng Dai   +14 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Assessing the potential for traffic carbon emission reductions through residential travel mode shifts: insights from massive vehicle trajectory data and scenario simulations

International Journal of Applied Earth Observations and Geoinformation
The choice of transportation mode by residents significantly affects road traffic carbon emissions. Recent studies have explored the carbon reduction effects of green travel behaviors, such as bicycle-sharing and metro travel.
Shaoying Li, Shaoli Li, Shuyuan Xu, Hanwen Xu, Xuanting Chen, Quan Mu, Zhangzhi Tan   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source