Results 81 to 90 of about 734,199 (300)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Assessing the potential for traffic carbon emission reductions through residential travel mode shifts: insights from massive vehicle trajectory data and scenario simulations

International Journal of Applied Earth Observations and Geoinformation
The choice of transportation mode by residents significantly affects road traffic carbon emissions. Recent studies have explored the carbon reduction effects of green travel behaviors, such as bicycle-sharing and metro travel.
Shaoying Li, Shaoli Li, Shuyuan Xu, Hanwen Xu, Xuanting Chen, Quan Mu, Zhangzhi Tan   +6 more
doaj   +1 more source

The HPx software for multicomponent reactive transport during variably-saturated flow: Recent developments and applications [PDF]

, 2018
HPx is a multicomponent reactive transport model which uses HYDRUS as the flow and transport solver and PHREEQC-3 as the biogeochemical solver.
Jacques, Diederik, Mallants, Dirk, Simunek, Jiri, van Genuchten, Martinus Th   +3 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of a Rigid Gas Diffusion Media Applied as Distributor of Reagents in a PEMFC in Operation, Part I: Dry Gases.

International Journal of Electrochemical Science, 2009
Several mass transport phenomena develop during the operation of a PEMFC, each one of this generates a mechanical-physics resistance to some extent, implying limitations during operation.
C. Moisés Bautista Rodríguez, M.G. Araceli Rosas Paleta, J. Antonio Rivera Marquez, A. Belén Tapia Pachuca, J. Roberto García de la Vega   +4 more
doaj   +1 more source

Validity of approximations applied in calculations of single-wall metallic carbon nanotube current-voltage characteristics

, 2012
The calculation results of dependencies of electric current in the infinitely long single-wall metallic carbon nanotubes of armchair type with different diameter values on the strength of constant and uniform longitudinal electric field applied to them ...
Pozdnyakov, Dmitry
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Two-stage oxidation of petrogenic organic carbon in a rapidly exhuming small mountainous catchment

Communications Earth & Environment
Globally, the oxidative flux of petrogenic organic carbon rivals the drawdown by silicate weathering and burial of biospheric carbon. Where and how petrogenic organic carbon is susceptible to degradation along the short-path river-marine continuum in ...
Wan-Yin Lien, Chih-Tung Chen, Yun-Hsuan Lee, Chih-Chieh Su, Pei-Ling Wang, Li-Hung Lin   +5 more
doaj   +1 more source

Integrating functional diversity, food web processes, and biogeochemical carbon fluxes into a conceptual approach for modeling the upper ocean in a high-CO2 world [PDF]

, 2005
Marine food webs influence climate by channeling carbon below the permanent pycnocline, where it can be sequestered. Because most of the organic matter exported from the euphotic zone is remineralized within the "upper ocean" (i.e., the water column ...
Legendre, Louis, Rivkin, Richard B.
core   +1 more source